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US 2003/0199458 A1Published application
Amido macrolides
AssigneeKosan Biosciences, Inc.
InventorsGary Ashley, Simon James Shaw, Yandong Li
Life of this patent
Estimating the term…
Abstract
Various macrolide compounds such as those having the following formulas are provided where the variables have the values provided herein. 1
Claims31
A compound or pharmaceutically acceptable salt thereof having the formula
- 121
- wherein
- R1 is C1-C8 substituted or unsubstituted alkyl, C2-C8 substituted or unsubstituted alkenyl, C2-C8 substituted or unsubstituted alkynyl, C4-C15 substituted or unsubstituted aryl, C5-C20 substituted or unsubstituted arylalkyl, C5-C20 substituted or unsubstituted biarylalkyl, C5-C20 substituted or unsubstituted arylalkenyl, or C5-C20 substituted or unsubstituted arylalkynyl;
- R2 is H, C1-C4 substituted or unsubstituted alkyl, C2-C4 substituted or unsubstituted alkenyl, or C2-C4 substituted or unsubstituted alkynyl;
- R3 is H, C1-C4 alkanoyl, or benzoyl;
- R4is H or OH;
- R5 is H, OH, C1-C4 alkoxy, C2-C4 alkenyloxy, or C2-C4 alkynyloxy;
- R6 is OH or OMe;
- and
- m=0-2.
7 more elements
A compound or pharmaceutically acceptable salt thereof having the formula
- 126
- wherein
- R3 is H, C1-C4 alkanoyl, or benzoyl;
- R4 is H or OH;
- R5 is H, C1-C4 alkoxy, C2-C4 alkenyloxy, or C2-C4 alkynyloxy;
- R8 is H or F;
- and
- m=0-2.
5 more elements
A compound or pharmaceutically acceptable salt thereof having the formula
- 129
- wherein
- R1 is C1-C8 substituted or unsubstituted alkyl, C2-C8 substituted or unsubstituted alkenyl, C2-C8 substituted or unsubstituted alkynyl, C4-C15 substituted or unsubstituted aryl, C5-C20 substituted or unsubstituted arylalkyl, C5-C20 substituted or unsubstituted biarylalkyl, C5-C20 substituted or unsubstituted arylalkenyl, or C5-C20 substituted or unsubstituted arylalkynyl;
- R2 is H, C1-C4 substituted or unsubstituted alkyl, C2-C4 substituted or unsubstituted alkenyl, or C2-C4 substituted or unsubstituted alkynyl;
- R3 is H, C1-C4 alkanoyl, or benzoyl;
- R4 is H or OH;
- R5 is H, C1-C4 alkoxy, C2-C4 alkenyloxy, or C2-C4 alkynyloxy;
- R8 is H or F;
- and
- m=0-2.
7 more elements
A compound or pharmaceutically acceptable salt thereof having the formula
- 132
- wherein
- R1 is C1-C8 substituted or unsubstituted alkyl, C2-C8 substituted or unsubstituted alkenyl, C2-C8 substituted or unsubstituted alkynyl, C4-C15 substituted or unsubstituted aryl, C5-C20 substituted or unsubstituted arylalkyl, C5-C20 substituted or unsubstituted biarylalkyl, C5-C20 substituted or unsubstituted arylalkenyl, or C5-C20 substituted or unsubstituted arylalkynyl;
- R2 is H, C1-C4 substituted or unsubstituted alkyl, C2-C4 substituted or unsubstituted alkenyl, or C2-C4 substituted or unsubstituted alkynyl;
- R3 is H, C1-C4 alkanoyl, or benzoyl;
- R5 is H, C1-C4 alkoxy, C2-C4 alkenyloxy, or C2-C4 alkynyloxy;
- R8 is H or F;
- X is O or NR7, wherein R7 is H, C1-C4 alkyl, or C6-C20 arylalkyl;
- and
- m=0-2.
7 more elements
A compound or pharmaceutically acceptable salt thereof having the formula:
- 136
- wherein
- R1 is C1-C8 substituted or unsubstituted alkyl, C2-C8 substituted or unsubstituted alkenyl, C2-C8 substituted or unsubstituted alkynyl, C4-C15 substituted or unsubstituted aryl, C5-C20 substituted or unsubstituted arylalkyl, C5-C20 substituted or unsubstituted biarylalkyl, C5-C20 substituted or unsubstituted arylalkenyl, or C5-C20 substituted or unsubstituted arylalkynyl;
- R2 is H, C1-C4 substituted or unsubstituted alkyl, C2-C4 substituted or unsubstituted alkenyl, or C2-C4 substituted or unsubstituted alkynyl;
- R4 is H or OH;
- R6 is OH or OMe;
- R9 is H or C1-C4 alkyl;
- and
- m=0-2.
6 more elements
Dependencies are inferred from the claim text.