Antigenic peptides reacting with anti-ovary antibodies
AssigneeBio Merieux
InventorsColette Jolivet-Reynaud, Gilbert G. Faure, Pascal Dalbon, Michel Jolivet, Marie-Christine Bene
Life of this patent
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Abstract
An oligopeptides comprising the following sequence Thr Gln Cys His Cys Gly Lys Cys (SEQ ID NO: 5) may be used as an antigenic compound capable of being recognized by anti-ovary antibodies and as an immunogenic compound capable of inducing the production of anti-ovary antibodies. In addition, the oligopeptides may be used to detect and/or quantify anti-ovary antibodies.
Claims20
An oligopeptide consisting of:
- a sequence selected from the group consisting of a reference peptide sequence SEQ ID NO:
- 5, SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, and SEQ ID NO:
- 4, or
- any peptide sequence that is a functional variant of said reference sequence SEQ ID NO:
- 5 in that it displays an antigenicity and/or an immunogenicity toward anti-ovary antibodies identical or similar to the antigenicity and/or the immunogenicity of the reference peptide, wherein the functional variant differs from said reference sequence by modification of the hydrocarbon residue of at least one amino acid of said reference sequence.
A process for detection and/or quantification of anti-ovary antibodies in a biological sample, comprising:
- placing said biological sample in contact with at least one oligopeptide comprising a reference peptide sequence SEQ ID NO:
- 5, or any peptide sequence that is a functional variant of said reference sequence in that it displays an antigenicity and/or an immunogenicity toward anti-ovary antibodies identical or similar to the antigenicity and/or the immunogenicity of the reference peptide, and
- observing the formation of an antigen-antibody complex between said oligopeptide and an anti-ovary antibody.
A reagent for detection and/or quantification of anti-ovary antibodies containing:
- (a) at least one oligopeptide comprising a reference peptide sequence SEQ ID NO:
- 5, or any peptide sequence that is a functional variant of said reference sequence in that it displays an antigenicity and/or an immunogenicity toward anti-ovary antibodies identical or similar to the antigenicity and/or the immunogenicity of the reference peptide, and
- (b) a solid support.
Dependencies are inferred from the claim text.