Enhancing neurotrophin-induced neurogenesis by endogenous neural progenitor cells by concurrent overexpression of brain derived neurotrophic factor and an inhibitor of a pro-gliogenic bone morphogenetic protein

A method of recruiting neurons to a subject's brain comprising:

• providing a neurotrophic factor;
• providing an inhibitor of pro-gliogenic bone morphogenetic proteins;
• and
• administering the neurotrophic factor and the inhibitor into the subject's lateral ventricles or ventricular wall under conditions effective to recruit neurons to the brain of the subject.

A method of treating a neurodegenerative condition comprising:

• providing a neurotrophic factor;
• providing an inhibitor of pro-gliogenic bone morphogenetic proteins;
• and
• administering the neurotrophic factor and the inhibitor into the subject's lateral ventricles or ventricular zone wall under conditions effective to treat a neurodegenerative condition.

The method of introducing a therapeutic protein into a subject's brain and spinal cord, said method comprising:

• introducing a nucleic acid molecule encoding the therapeutic protein into the subject's ependyma;
• expressing the protein from the nucleic acid molecule within the subject's ependyma;
• and
• permitting the expressed protein to migrate within the subject's brain and spinal cord.