Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
AssigneeNutrition 21
InventorsMichael Climo, Ellen Murphy, Gordon Archer
Life of this patent
Estimating the term…
Abstract
Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even staphylococci that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include β-lactams and glycopeptides.
Claims17
A method of treating a staphylococcal infection in a mammal in need of same, comprising administering an antimicrobial agent thereto while suppressing the formation of staphylococci mutant strains resistant to said antimicrobial agent, said method comprising simultaneously administering an amount of an anti-staphylococcal agent whose activity is mediated by cleavage of the glycine-containing cross-links of peptidoglycans of the cell wall of staphylococci (peptidoglycan active agent) and an amount of another antibiotic effective against sensitive staphylococci, wherein said antibiotic activity is mediated by cell-wall activity (cell wall active antibiotic), whereby the formation of staphylococci mutant strains resistant to said peptidoglycan active agent is suppressed, wherein said amount of peptidoglycan active agent and said amount of said cell-wall active antibiotic are each individually sufficient to be therapeutically effective against sensitive staphylococci, when co-administered.
A composition effective in the treatment of staphylococcal infection in a mammal, comprising, as active agents, an anti-staphylococcal agent whose activity is mediated by cleavage of the glycine-containing cross-links of peptidoglycans of the cell wall of staphylococci (a peptidoglycan active agent) and an amount of another antibiotic effective against sensitive staphylococci, wherein said antibiotic activity is mediated by cell wall activity (a cell wall active antibiotic), further comprising a pharmaceutically acceptable carrier, wherein each of said peptidoglycan active agent and cell-wall active antibiotic are individually present in amounts which are therapeutically effective in treating a sensitive staphylococcal infection.
Dependencies are inferred from the claim text.