US 2003/0199426 A1 · Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels

Abstract

The present invention refers to a pharmaceutical composition suitable for the transdermal or transmucosal administration of one or more active agents, in form of a gel or a solution, comprising as a permeation enhancers a combination of: a) saturated fatty alcohol of formula CH3—(CH2)n—CH2OH or saturated fatty acid CH3—(CH2)n—CH2COOH wherein n is an integer number 8÷22, preferably 8÷12, most preferably 10, or unsaturated fatty alcohol or fatty acid of formula: CH3(CnH2(n−1))—OH or CH3(CnH2(n−1))—COOH wherein n is an integer number 8÷22, b) a ternary vehicle or carrier consisting of a C1÷C4 alkanol, a polyalcohol in particular propylenglycol and water, c) optionally also a monoalkylether of diethylenglycol.

Claims10

Dependent claims

Pharmaceutical composition suitable for the transdernal or transmucosal administration of one or more active agents, in form of a gel or a solution, comprising as a permeation enhancers a combination of:

a) saturated fatty alcohol of formula CH3—(CH2)n—CH2OH or saturated fatty acid CH3—(CH2)n—CH2COOH wherein n is an integer number 8÷22, preferably 8÷12, most preferably 10, or unsaturated fatty alcohol or fatty acid of formula:
CH3(CnH2(n−1))—OH or CH3(CnH2(n−1))—COOH wherein n is an integer number 8÷22,
b) a ternary vehicle or carrier consisting of a C1÷C4 alkanol, a polyalcohol in particular propylenglycol and water,
c) optionally also a monoalkylether of diethylenglycol.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

10/343,570Filed 19 May 2003

Priority

EP PCT EP00 075333 Aug 2000

Published

23 Oct 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 9/006
Mouth and digestive tract, i.e. intraoral and peroral administration: oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or…
A61K 9/0014
Galenical forms characterised by the site of application: skin, i.e. galenical aspects of topical compositions
A61K 9/06
Medicinal preparations characterised by special physical form: ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
A61K 31/551
Having seven-membered rings, e.g. azelastine, pentylenetetrazole: having two nitrogen atoms, e.g. dilazep

Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels

Life of this patent

Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels

Life of this patent

Abstract

Claims10