Compositions and methods for treatment of hyperplasia
OwnerNeil P. Desai, Patrick Soon-Shionginventors
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Abstract
In accordance with the present invention, there are provided methods for treating hyperplasia in a subject in need thereof. In another aspect of the invention, there are provided methods for reducing neointimal hyperplasia associated with vascular interventional procedures. Formulations contemplated for use herein comprise proteins and at least one pharmaceutically active agent.
Claims30
A method for treating hyperplasia in a subject in need thereof, said method comprising administering to said subject an effective amount of a composition comprising drug and protein.
A method for reducing neointimal hyperplasia associated with vascular interventional procedure(s) in a subject in need thereof, said method comprising administering to said subject an effective amount of a composition comprising at least one drug and protein.
A method to reduce proliferation and cell migration in a subject undergoing a vascular interventional procedure, said method comprising systemically administering a formulation comprising a drug that inhibits proliferation and cell migration, and a biocompatible protein to said subject before, during or after said procedure.
A composition for treatment of hyperplasia, said composition comprising at least one drug and protein.
A composition for reducing neointimal hyperplasia associated with vascular interventional procedure(s), said composition comprising at least one drug and protein.
A method to reduce the toxicity of a drug that inhibits proliferation and migration of cells, said method comprising combining said drug with :
- biocompatible protein.
A pharmaceutical formulation with reduced toxicity, said formulation comprising a drug that inhibits proliferation and cell migration, and a biocompatible protein.
Dependencies are inferred from the claim text.