Method of treatment and/or prophylaxis
OwnerMaree Therese Smith, Lindsay Charles Browninventors
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Abstract
The present invention is directed to the use of angiotensin II receptor I (AT1 receptor) antagonists for the treatment, prophylaxis, reversal and/or symptomatic relief of a neuropathic condition, especially a peripheral neuropathic condition such as painful diabetic neuropathy, in vertebrate animals and particularly in human subjects. The present invention also discloses the use of AT1 receptor antagonists for preventing, attenuating or reversing the development of reduced opioid sensitivity, and more particularly reduced opioid analgesic sensitivity, in individuals and especially in individuals having, or at risk of developing, a neuropathic condition.
Claims64
A method for treating or preventing a neuropathic condition in a subject, the method comprising administering to the subject an AT1 receptor antagonist in an amount that is effective for the treatment or prophylaxis of the neuropathic condition.
A method for preventing or attenuating peripheral neuropathic pain in a subject, the method comprising administering to the subject an amount of candesartan or a pharmaceutically compatible salt thereof that is effective for preventing or attenuating the neuropathic pain.
A method for preventing, attenuating or reversing the development of analgesic hyposensitivity to an opioid receptor agonist in a subject, the method comprising administering to the subject an AT1 receptor antagonist in an amount that is effective for the prevention, attenuation or reversal of the analgesic hyposensitivity to the opioid receptor agonist.
A method for producing analgesia in a subject having, or at risk of developing, reduced analgesic sensitivity to an opioid receptor agonist, the method comprising administering to the subject an AT1 receptor antagonist and an opioid analgesic.
A method of preventing or reversing the development of analgesic hyposensitivity to an opioid receptor agonist in a subject, the method comprising administering an AT1 receptor antagonist together with the opioid receptor agonist.
A method of preventing or reversing the development of tolerance to an opioid receptor agonist in a subject, the method comprising administering an AT1 receptor antagonist and the opioid receptor agonist.
A method for producing analgesia in a subject having or at risk of developing a neuropathic condition, the method comprising administering to the subject an AT1 receptor antagonist in an amount that is effective for preventing, attenuating or reversing a reduced analgesic sensitivity, and an opioid analgesic.
An analgesic composition comprising an AT1 receptor antagonist and an opioid analgesic, each in an amount effective to produce analgesia in a subject having or at risk of developing reduced analgesic sensitivity to an opioid receptor agonist.
A composition comprising candesartan and morphine.
A composition comprising candesartan and oxycodone.
Dependencies are inferred from the claim text.