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US 2003/0199103 A1Published application
Novel amino acid sequences for human epidermal growth factor-like polypeptides
AssigneeCuraGen Corporation
InventorsRichard A. Shimkets, Elma Fernandes, John Herrman, Corine Vernet
Life of this patent
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Abstract
This application is drawn to novel amino acid sequences for mammalian polypeptides that have sequence similarity to a protein fragment of human epidermal growth factor. The polypeptides are novel secreted proteins of approximately 708 amino acids.
Claims15
A substantially purified polypeptide comprising an amino acid sequence selected from any one of the following:
- (a) a polypeptide of SEQ ID NO:
- 34;
- (b) a polypeptide having one or more conservative amino acid substitutions to the polypeptide of SEQ ID NO:
- 34;
- or
- (c) a mutant or variant of the polypeptide of SEQ ID NO:
- 34.
4 more elements
A method of diagnosing a pathological condition associated with aberrant SEQ ID NO:
- 34 polypeptide expression or activity in a subject, the method comprising:
- (a) providing a protein sample from said subject;
- (b) providing a control protein sample;
- (c) measuring the amount of SEQ ID NO:
- 34 polypeptide in said subject sample;
- and
- (d) comparing the amount of SEQ ID NO:
- 34 polypeptide in said subject protein sample to the amount of SEQ ID NO:
- 34 polypeptide in said control protein sample,
- wherein an alteration in the amount of SEQ ID NO:
- 34 polypeptide in said subject protein sample relative to the amount of SEQ ID NO:
- 34 polypeptide in said control protein sample indicates the subject has said pathological condition.
9 more elements
A method for identifying a compound that modulates the activity of a SEQ ID NO:
- 34 protein, the method comprising:
- (a) contacting SEQ ID NO:
- 34 protein with a compound;
- and
- (b) determining whether SEQ ID NO:
- 34 protein activity has been altered.
3 more elements
Dependencies are inferred from the claim text.