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US 2003/0199090 A1Published application
Compositions and methods for drug delivery using pH sensitive molecules
AssigneeMirus Bio Corporation
InventorsSean D. Monahan, Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, David B. Rozema
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Abstract
A system relating to the delivery of desired compounds (e.g., drugs and nucleic acids) into cells using pH-sensitive delivery systems. The system provides compositions and methods for the delivery and release of a compound to a cell.
Claims35
A process for transfecting a cell, comprising:
- a) attaching a labile linkage to a polymeric membrane-active compound;
- b) adding the polymeric membrane-active compound to a solution containing the nucleic acid;
- c) introducing the polymeric membrane-active compound and nucleic acid to a cell;
- and,
- d) transfecting the cell.
2 more elements
A process for transfecting a cell, comprising:
- a) attaching more than one labile linkage to a polymer;
- b) adding the polymer to a solution containing the nucleic acid;
- c) introducing the polymer and nucleic acid to a cell;
- and,
- d) transfecting the cell.
2 more elements
A complex for delivering a nucleic acid to a cell, comprising:
- a) a polymeric membrane-active compound containing a labile bond;
- b) a polymer;
- and,
- c) the nucleic acid.
1 more element
A complex for transfecting a cell, comprising:
- a) a polymeric membrane-active compound containing a labile bond;
- b) a polymer containing a labile bond;
- and,
- c) the nucleic acid.
1 more element
A process for transfecting a cell, comprising:
- a) forming a labile linkage between two compounds to form a complex containing nucleic acid;
- b) delivering the complex to the cell;
- c) removing the labile linkage;
- and,
- d) transfecting the cell.
2 more elements
A process for transfecting a cell, comprising:
- a) forming a polymer containing labile linkages
- b) adding the polymer to a solution containing a nucleic acid;
- c) introducing the polymer and nucleic acid to the cell;
- and,
- d) transfecting the cell.
2 more elements
Dependencies are inferred from the claim text.