Minicell-based gene therapy
AssigneeVaxiion Therapeutics, Inc.
InventorsRoger A. Sabbadini, Neil Berkley, Mark W. Surber
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Abstract
The invention provides compositions and methods for the production of achromosomal and anucleate cells useful for applications such as diagnositic and therapeutic uses, as well as research tools and agents for drug discovery.
Claims20
A minicell comprising a nucleic acid, wherein said nucleic acid comprises eukaryotic expression sequences and eubacterial expression sequences, each of which is independently operably linked to an ORF.
A minicell comprising a first and second nucleic acid, wherein said first nucleic acid comprises eukaryotic expression sequences operably linked to a first ORF, and a second nucleic acid, wherein said second nucleic acid comprises eubacterial expression sequences operably linked to a second ORF.
A method of introducing into and expressing a nucleic acid in an organism, comprising contacting a minicell to a cell of said organism, wherein said minicell comprises said nucleic acid.
Dependencies are inferred from the claim text.