Growth arrest homeobox gene
AssigneeCase Western Reserve University
InventorsDavid H. Gorski, Kenneth Walsh
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Abstract
A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the “Gax gene” and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.
Claims32
A DNA sequence encoding a protein or portion thereof, which inhibits vascular smooth muscle cell proliferation.
An isolated protein which inhibits vascular smooth muscle cell growth.
A method for inhibiting the proliferation of eukaryotic cells, comprising the following steps:
- a. providing nucleic acid sequence encoding a protein, or portion thereof, which inhibits vascular smooth muscle cell proliferation;
- and
- b. administering said nucleic acid or said protein to the cells.
Dependencies are inferred from the claim text.