Interleukin-17 receptor homologue
OwnerScott R. Presnell, Steven K. Burkhead +1inventors
InventorsScott R. Presnell, Steven K. Burkhead, Sarah L. Pownder
Life of this patent
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Abstract
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”
Claims44
An isolated polypeptide, comprising an amino acid sequence that is at least 70% identical to a reference amino acid sequence selected from the group consisting of:
- (a) amino acid residues 21 to 452 of SEQ ID NO:
- 2, (b) amino acid residues 21 to 435 of SEQ ID NO:
- 10, (c) amino acid residues 21 to 677 of SEQ ID NO:
- 2, and (d) amino acid residues 1 to 692 of SEQ ID NO:
- 2, wherein the isolated polypeptide specifically binds with an antibody that specifically binds with a polypeptide consisting of either the amino acid sequence of SEQ ID NO:
- 2, or the amino acid sequence of SEQ ID NO:
- 10.
An isolated nucleic acid molecule that encodes a Zcytor14 polypeptide, wherein the nucleic acid molecule is selected from the group consisting of:
- (a) a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:
- 3, (b) a nucleic acid molecule encoding an amino acid sequence that comprises either amino acid residues 21 to 677 of SEQ ID NO:
- 2 or amino acid residues 21 to 673 of SEQ ID NO:
- 10, and (c) a nucleic acid molecule that remains hybridized following stringent wash conditions to a nucleic acid molecule comprising the nucleotide sequence of nucleotides 214 to 2184 of SEQ ID NO:
- 1, or the complement of nucleotides 214 to 2184 of SEQ ID NO:
- 1.
An isolated polypeptide consisting of either amino acid residues 21 to 452 of SEQ ID NO:
- 2, or amino acid residues 21 to 435 of SEQ ID NO:
- 10.
An isolated polypeptide comprising an amino acid sequence that is at least 95% identical with SEQ ID NO:
- 2, wherein the polypeptide initiates or sustains inflammation.
An isolated polypeptide comprising amino acid residues 21 to 452 of SEQ ID NO:
- 2.
An isolated polypeptide comprising an amino acid sequence that is at least 95% identical with SEQ ID NO:
- 10, wherein the polypeptide initiates or sustains inflammation.
An isolated polypeptide comprising amino acid residues 21 to 435 of SEQ ID NO:
- 10.
An isolated polypeptide comprising a soluble amino acid sequence that is at least 95% identical to amino acid residues 21 to 452 of SEQ ID NO:
- 2, wherein the polypeptide inhibits inflammation.
An isolated polypeptide comprising a soluble amino acid sequence that is at least 95% identical to amino acid residues 21 to 435 of SEQ ID NO:
- 10, wherein the polypeptide inhibits inflammation.
Dependencies are inferred from the claim text.