Method for monitoring the immune response and predicting clinical outcomes in transplant recipients
AssigneeCylex, Inc.
InventorsJudith A. Britz, Peter R. Sottong, Richard J. Kowalski
Life of this patent
Estimating the term…
Abstract
Methods for monitoring the immune response and predicting clinical outcomes for patients on immunosuppressive drugs (such as transplant patients) are provided. The methods are based on the measurement of an intracellular metabolic marker in lymphocytes (such as ATP) as an indicator of a patient's immune response.
Claims49
A method of assessing an immune response in a patient, comprising the steps of
- determining a value of said immune response in a sample of lymphocytes from said patient;
- comparing said value with values in a reference set comprising ranges of values of immunological responses for lymphocytes;
- and
- assessing said immune response in said patient based on a comparison made in said comparing step.
A method for predicting a clinical outcome or determining a treatment course in a patient, wherein at least one immunosuppressive drug is administered to said patient, comprising the steps of
- determining a value of an immune response in at least one sample of lymphocytes from said patient;
- comparing said value with values in a reference set comprising ranges of values of immunological response for lymphocytes;
- and
- predicting said clinical outcome or determining said treatment course for said patient based on a comparison made in said comparing step.
A method of monitoring an immune response in a patient prior to or currently receiving at least one immunosuppressive drug, comprising the steps of
- determining a value of an immunological response in a single sample of lymphocytes from said patient prior to or after administration of at least one immunosuppressive drug;
- comparing said value of the sampled lymphocytes with a reference set having defined ranges of human immunological responses at various levels of reactivity of lymphocytes;
- and
- assessing said immune response in said patient based on a comparison made in said comparing step.
A method for predicting a clinical outcome or treatment course in a patient prior to receiving at least one immunosuppressive drug, comprising the steps of
- determining a value of an immunological response of a set or subset of lymphocytes in a single blood sample from said patient prior to or after administration of said at least one immunosupressive drug;
- comparing said value of the sampled lymphocytes with a reference set having defined ranges of human immunological response at various levels of reactivity of lymphocytes;
- and
- predicting said clinical outcome or determining said treatment course for said patient based on a comparison made in said comparing step.
A method for predicting a clinical outcome or treatment course in a patient receiving at least one immunosuppressive drug, comprising the steps of
- determining a value of an immunological response of a sample of lymphocytes from said patient prior to administration of any drug and at least one additional sample of lymphocytes from said patient after receiving said at least one immunosupressive drug;
- comparing said values of the sampled lymphocytes with a reference set having defined ranges of human immunological response at various levels of reactivity of lymphocytes and with one another;
- and
- predicting said clinical outcome or determining said treatment course for said patient based on a comparison made in said comparing step.
A method for predicting a clinical outcome or treatment course in a patient receiving at least one immunosuppressive drug, comprising the steps of
- determining a value of an immunological response of two or more samples of lymphocytes collected over time from said patient after receiving at least one immunosupressive drug;
- comparing said values of the sampled lymphocytes with a reference set having defined ranges of human immunological response at various levels of reactivity of lymphocytes and with one another;
- and
- predicting said clinical outcome or determining said treatment course for said patient based on a comparison made in said comparing step.
A method for assessing a pharmacodynamic impact of an immunosupressive drug in a non-transplant patient, comprising the steps of
- determining a value of an immune response in at least one sample of lymphocytes from said non-transplant patient;
- comparing said value with values in a reference set comprising ranges of values of immunological response for lymphocytes;
- and
- assessing said pharmacodynamic impact of said immunosupressive drug based on a comparison made in said comparing step.
Dependencies are inferred from the claim text.