US 2003/0198975 A1Published application

Proteins associated with cell growth, differentiation, and death

AssigneeIncyte Genomics, Inc.

InventorsYalda Azimzai, Janice Au-Young, Sajeev Batra, Mariah R. Baughn, Shanya D. Becha, Mark L. Borowsky, Neil Burford, Li Ding, Vicki S. Elliott, Brooke M. Emerling, Ameena R. Gandhi, Kimberly J. Gietzen, Jennifer A. Griffin, April J. A. Hafalia, Cynthia D. Honchell, Preeti G. Lal, Soo Yeun Lee, Dyung Aina M. Lu, Chandra S. Arvizu, Jayalaxmi Ramkumar, Roopa M. Reddy, Madhusudan S. Sanjanwala, Y. Tom Tang, Narinder K. Chawla, Yu-Mei E. Wang, Bridget A. Warren, Yuming Xu, Junming Yang, Monique G. Yao, Henry Yue, Yeganeh Zebarjadian

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Abstract

The invention provides human proteins associated with cell growth, differentiation, and death (CGDD) and polynucleotides which identify and encode CGDD. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CGDD.

Claims97

Dependent claims

An isolated polypeptide selected from the group consisting of:

a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:1-21,
b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:3-4, SEQ ID NO:6, SEQ ID NO:8-9, SEQ ID NO:
11-12, SEQ ID NO:14-16, SEQ ID NO:18-21,
c) a polypeptide comprising a naturally occurring amino acid sequence at least 93% identical to the amino acid sequence of SEQ ID NO:1,
d) a polypeptide comprising a naturally occurring amino acid sequence at least 95% identical to the amino acid sequence of SEQ ID NO:2,
e) a polypeptide comprising a naturally occurring amino acid sequence at least 96% identical to the amino acid sequence of SEQ ID NO:5,
f) a polypeptide comprising a naturally occurring amino acid sequence at least 98% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:7 and SEQ ID NO:10,
g) a polypeptide comprising a naturally occurring amino acid sequence at least least 99% identical to the polynucleotide sequence of SEQ ID NO:17,
h) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1-21, and
i) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1-21.

7 more elements

An isolated polynucleotide selected from the group consisting of:

a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:22-42,
b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:22-25, SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:30, SEQ ID NO:32-37, SEQ ID NO:39-42,
c) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 92% identical to the polynucleotide sequence of SEQ ID NO:26,
d) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 98% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:28 and SEQ ID NO:31,
e) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 99% identical to the polynucleotide sequence of SEQ ID NO:38,
f) a polynucleotide complementary to a polynucleotide of a),
g) a polynucleotide complementary to a polynucleotide of b),
h) a polynucleotide complementary to a polynucleotide of c),
i) a polynucleotide complementary to a polynucleotide of d),
j) a polynucleotide complementary to a polynucleotide of e), and
k) an RNA equivalent of a)-j).

8 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/287,218Filed 31 Oct 2002
Priority: WO PCT/US02/111525 Apr 2002
Published: 23 Oct 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification31 codes

C07K 14/4738
Not used: cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
A61P 7/06
Drugs for disorders of the blood or the extracellular fluid: antianaemics

Family

Application60/282,110Us provisional application · filed 6 Apr 2001
Application60/283,294Us provisional application · filed 11 Apr 2001
Application60/286,820Us provisional application · filed 26 Apr 2001
Application60/287,228Us provisional application · filed 27 Apr 2001
Application60/291,662Us provisional application · filed 16 May 2001
Application60/291,846Us provisional application · filed 18 May 2001
Application60/293,727Us provisional application · filed 25 May 2001
Application60/295,263Us provisional application · filed 1 Jun 2001
Application60/295,340Us provisional application · filed 1 Jun 2001
Application60/349,705Us provisional application · filed 15 Jan 2002
Application10/287,218Continuation · filed 31 Oct 2002
US 2003/0198975 A1This patent

From the US filing history. Foreign family members aren’t listed.