Haplotypes of the TACR2 gene

A method for haplotyping the tachykinin receptor 2 (TACR2) gene of an individual, which comprises identifying the phased sequence of nucleotides at PS1-PS27 for each copy of the individual's TACR2 gene and assigning to the individual a TACR2 haplotype pair that is consistent with each of the phased sequences, wherein the TACR2 haplotype pair is selected from the group consisting of the TACR2 haplotype pairs shown in the table immediately below:

• 17 PS PS Posi- No. tion Haplotype Pair(c)(Part 1) (a) (b) 7/2 8/4 8/8 8/10 8/14 8/16 8/17 8/18 1 1001 G/A G/G G/G G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 C/T C/C C/C C/C C/C C/C C/C C/C 4 1231 T/T T/C T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 C/T C/T C/C C/C C/T C/T C/T C/T 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 G/G G/A G/G G/G G/A G/G G/G G/G 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/T T/T T/T T/T T/T T/T T/T T/T 12 10368 C/C T/T T/T T/T T/T T/C T/C T/T 13 10373 G/G G/G G/G G/T G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/G G/G G/G G/G 17 10440 T/T T/T T/T T/T T/T T/T T/T T/T 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/A A/A A/A A/A 20 12832 G/G G/G G/G G/G G/G G/A G/G G/G 21 12836 C/T C/C C/C C/C C/C C/C C/C C/C 22 12892 A/A A/A A/A A/A A/A A/A A/A A/A 23 12997 T/T T/T T/T T/T T/T T/T T/T T/T 24 13285 T/C T/T T/T T/T T/T T/T T/T T/T 25 13305 T/T T/T T/T T/T T/T T/T T/T T/T 26 13306 T/T T/T T/T T/T T/T T/C T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 2) (a) (b) 8/20 8/24 8/26 8/28 11/1 11/6 11/8 11/11 1 1001 G/G G/G G/G G/G G/A G/G G/G G/G 2 1052 C/C C/C C/C C/T C/C C/C C/C C/C 3 1147 C/T C/T C/T C/C C/T C/C C/C C/C 4 1231 T/T T/T T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 C/C C/T C/T C/C T/T T/C T/C T/T 8 1541 G/A G/G G/G G/G G/G G/G G/G G/G 9 1873 G/G G/G G/G G/G A/A A/G A/G A/A 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/A T/T T/T T/A T/T T/T T/T T/T 12 10368 T/C T/C T/C T/C C/C C/C C/T C/C 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/A T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/A G/G G/G G/A G/G G/G G/G G/G 17 10440 T/C T/T T/T T/C T/T T/T T/T T/T 18 10460 A/A A/A A/G A/A A/A A/A A/A A/A 19 12795 A/G A/A A/A A/G A/A A/A A/A A/A 20 12832 G/G G/G G/G G/G A/G A/A A/G A/A 21 12836 C/C C/C C/C C/C C/C C/C C/C C/C 22 12892 A/G A/A A/A A/G A/A A/A A/A A/A 23 12997 T/C T/T T/T T/C T/T T/T T/T T/T 24 13285 T/T T/T T/T T/T T/T T/T T/T T/T 25 13305 T/C T/T T/T T/C T/T T/T T/T T/T 26 13306 T/T T/T T/T T/T C/T C/C C/T C/C 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 3) (a) (b) 11/14 11/25 13/1 13/3 13/5 13/7 13/8 13/9 1 1001 G/G G/G G/A G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 C/C C/T C/T C/C C/C C/C C/C C/C 4 1231 T/T T/T T/T T/C T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 T/T T/T T/T T/T T/C T/C T/C T/C 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 A/A A/G A/A A/A A/A A/G A/G A/G 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/T T/T T/T T/T T/T T/T T/T T/T 12 10368 C/T C/C C/C C/C C/T C/C C/T C/T 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/G G/G G/G G/G 17 10440 T/T T/T T/T T/T T/T T/T T/T T/T 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/A A/A A/A A/A 20 12832 A/G A/G G/G G/G G/G G/G G/G G/G 21 12836 C/C C/T C/C C/C C/C C/C C/C C/T 22 12892 A/A A/A A/A A/A A/A A/A A/A A/A 23 12997 T/T T/T T/T T/T T/T T/T T/T T/T 24 13285 T/T T/C T/T T/T T/T T/T T/T T/C 25 13305 T/T T/T T/T T/T T/T T/T T/T T/T 26 13306 C/T C/T T/T T/T T/T T/T T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 4) (a) (b) 13/11 13/12 13/13 13/14 13/19 13/21 13/22 13/27 1 1001 G/G G/G G/G G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 C/C C/C C/C C/C C/T C/T C/T C/T 4 1231 T/T T/T T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/A G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/G 7 1470 T/T T/T T/T T/T T/C T/C T/C T/T 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 A/A A/A A/A A/A A/G A/G A/G A/G 10 10333 C/C C/C C/C C/C C/T C/C C/C C/C 11 10342 T/T T/T T/T T/T T/A T/A T/T T/A 12 10368 C/C C/C C/C C/T C/C C/C C/T C/C 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/A T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/A G/A G/G G/A 17 10440 T/T T/T T/T T/T T/C T/C T/T T/C 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/ A A/A A/A A/A A/G A/G A/A A/G 20 12832 G/A G/G G/G G/G G/G G/G G/G G/G 21 12836 C/C C/C C/C C/C C/C C/C C/C C/C 22 12892 A/A A/A A/A A/A A/G A/G A/A A/G 23 12997 T/T T/T T/T T/T T/C T/C T/T T/C 24 13285 T/T T/T T/T T/T T/T T/T T/T T/T 25 13305 T/T T/T T/T T/T T/C T/C T/T T/C 26 13306 T/C T/T T/T T/T T/T T/T T/T T/T 27 13371 G/G G/A G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 5) (a) (b) 13/29 14/14 19/15 19/25 21/23 21/27 1 1001 G/G G/G G/G G/G G/G G/G 2 1052 C/T C/C C/C C/C C/C C/C 3 1147 C/C C/C T/C T/T T/T T/T 4 1231 T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G A/G A/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/G 7 1470 T/T T/T C/T C/T C/T C/T 8 1541 G/G G/G G/G G/G G/G G/G 9 1873 A/A A/A G/G G/G G/A G/G 10 10333 C/C C/C T/C T/C C/C C/C 11 10342 T/T T/T A/A A/T A/A A/A 12 10368 C/C T/T C/C C/C C/C C/C 13 10373 G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T A/T A/T 15 10382 T/T T/T T/C T/T T/T T/T 16 10393 G/G G/G A/G A/G A/G A/A 17 10440 T/T T/T C/T C/T C/T C/C 18 10460 A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A G/A G/A G/A G/G 20 12832 G/A G/G G/G G/G G/G G/G 21 12836 C/C C/C C/C C/T C/C C/C 22 12892 A/A A/A G/A G/A G/G G/G 23 12997 T/T T/T C/T C/T C/T C/C 24 13285 T/T T/T T/T T/C T/T T/T 25 13305 T/T T/T C/T C/T C/T C/C 26 13306 T/C T/T T/T T/T T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G (a)PS = polymorphic site;
• (b)Position of PS in SEQ ID NO:1;
• (c)Haplotype pairs are represented as 1st haplotype/2nd haplotype;
• with alleles of each haplotype # shown 5′ to 3′ as 1st polymorphism/2nd polymorphism in each column.

A method for predicting a haplotype pair for the tachykinin receptor 2 (TACR2) gene of an individual comprising:

• (a) identifying a TACR2 genotype for the individual, wherein the genotype comprises the nucleotide pair at two or more polymorphic sites (PS) selected from the group consisting of PS1, PS2, PS3, PS4, PS5, PS6, PS7, PS8, PS9, PS10, PS11, PS12, PS13, PS14, PS15, PS16, PS17, PS18, PS19, PS20, PS21, PS22, PS23, PS24, PS25, PS26 and PS27, wherein the selected PS have the position and alternative alleles shown in SEQ ID NO:1;
• (b) comparing the genotype to the haplotype pair data set forth in the table immediately below;
• and
• (c) determining which haplotype pair is consistent with the genotype of the individual and with the haplotype pair data
• 18 PS PS Posi- No. tion Haplotype Pair(c)(Part 1) (a) (b) 7/2 8/4 8/8 8/10 8/14 8/16 8/17 8/18 1 1001 G/A G/G G/G G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 C/T C/C C/C C/C C/C C/C C/C C/C 4 1231 T/T T/C T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 C/T C/T C/C C/C C/T C/T C/T C/T 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 G/G G/A G/G G/G G/A G/G G/G G/G 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/T T/T T/T T/T T/T T/T T/T T/T 12 10368 C/C T/T T/T T/T T/T T/C T/C T/T 13 10373 G/G G/G G/G GAT G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/G G/G G/G G/G 17 10440 T/T T/T T/T T/T T/T T/T T/T T/T 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/A A/A A/A A/A 20 12832 G/G G/G G/G G/G G/G G/A G/G G/G 21 12836 C/T C/C C/C C/C C/C C/C C/C C/C 22 12892 A/A A/A A/A A/A A/A A/A A/A A/A 23 12997 T/T T/T T/T T/T T/T T/T T/T T/T 24 13285 T/C T/T T/T T/T T/T T/T T/T T/T 25 13305 T/T T/T T/T T/T T/T T/T T/T T/T 26 13306 T/T T/T T/T T/T T/T T/C T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 2) (a) (b) 8/20 8/24 8/26 8/28 11/1 11/6 11/8 11/11 1 1001 G/G G/G G/G G/G G/A G/G G/G G/G 2 1052 C/C C/C C/C C/T C/C C/C C/C C/C 3 1147 C/T C/T C/T C/C C/T C/C C/C C/C 4 1231 T/T T/T T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 C/C C/T C/T C/C T/T T/C T/C T/T 8 1541 G/A G/G G/G G/G G/G G/G G/G G/G 9 1873 G/G G/G G/G G/G A/A A/G A/G A/A 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/A T/T T/T T/A T/T T/T T/T T/T 12 10368 T/C T/C T/C T/C C/C C/C C/T C/C 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/A T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/A G/G G/G G/A G/G G/G G/G G/G 17 10440 T/C T/T T/T T/C T/T T/T T/T T/T 18 10460 A/A A/A A/G A/A A/A A/A A/A A/A 19 12795 A/G A/A A/A A/G A/A A/A A/A A/A 20 12832 G/G G/G G/G G/G A/G A/A A/G A/A 21 12836 C/C C/C C/C C/C C/C C/C C/C C/C 22 12892 A/G A/A A/A A/G A/A A/A A/A A/A 23 12997 T/C T/T T/T T/C T/T T/T T/T T/T 24 13285 T/T T/T T/T T/T T/T T/T T/T T/T 25 13305 T/C T/T T/T T/C T/T T/T T/T T/T 26 13306 T/T T/T T/T T/T C/T C/C C/T C/C 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 3) (a) (b) 11/14 11/25 13/1 13/3 13/5 13/7 13/8 13/9 1 1001 G/G G/G G/A G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 C/C C/T C/T C/C C/C C/C C/C C/C 4 1231 T/T T/T T/T T/C T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 T/T T/T T/T T/T T/C T/C T/C T/C 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 A/A A/G A/A A/A A/A A/G A/G A/G 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/T T/T T/T T/T T/T T/T T/T T/T 12 10368 C/T C/C C/C C/C C/T C/C C/T C/T 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/G G/G G/G G/G 17 10440 T/T T/T T/T T/T T/T T/T T/T T/T 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/A A/A A/A A/A 20 12832 A/G A/G G/G G/G G/G G/G G/G G/G 21 12836 C/C C/T C/C C/C C/C C/C C/C C/T 22 12892 A/A A/A A/A A/A A/A A/A A/A A/A 23 12997 T/T T/T T/T T/T T/T T/T T/T T/T 24 13285 T/T T/C T/T T/T T/T T/T T/T T/C 25 13305 T/T T/T T/T T/T T/T T/T T/T T/T 26 13306 C/T C/T T/T T/T T/T T/T T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 4) (a) (b) 13/11 13/12 13/13 13/14 13/19 13/21 13/22 13/27 1 1001 G/G G/G G/G G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 C/C C/C C/C C/C C/T C/T C/T C/T 4 1231 T/T T/T T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/A G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/G 7 1470 T/T T/T T/T T/T T/C T/C T/C T/T 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 A/A A/A A/A A/A A/G A/G A/G A/G 10 10333 C/C C/C C/C C/C C/T C/C C/C C/C 11 10342 T/T T/T T/T T/T T/A T/A T/T T/A 12 10368 C/C C/C C/C C/T C/C C/C C/T C/C 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/A T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/A G/A G/G G/A 17 10440 T/T T/T T/T T/T T/C T/C T/T T/C 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/G A/G A/A A/G 20 12832 G/A G/G G/G G/G G/G G/G G/G G/G 21 12836 C/C C/C C/C C/C C/C C/C C/C C/C 22 12892 A/A A/A A/A A/A A/G A/G A/A A/G 23 12997 T/T T/T T/T T/T T/C T/C T/T T/C 24 13285 T/T T/T T/T T/T T/T T/T T/T T/T 25 13305 T/T T/T T/T T/T T/C T/C T/T T/C 26 13306 T/C T/T T/T T/T T/T T/T T/T T/T 27 13371 G/G G/A G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 5) (a) (b) 13/29 14/14 19/15 19/25 21/23 21/27 1 1001 G/G G/G G/G G/G G/G G/G 2 1052 C/T C/C C/C C/C C/C C/C 3 1147 C/C C/C T/C T/T T/T T/T 4 1231 T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G A/G A/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/G 7 1470 T/T T/T C/T C/T C/T C/T 8 1541 G/G G/G G/G G/G G/G G/G 9 1873 A/A A/A G/G G/G G/A G/G 10 10333 C/C C/C T/C T/C C/C C/C 11 10342 T/T T/T A/A A/T A/A A/A 12 10368 C/C T/T C/C C/C C/C C/C 13 10373 G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T A/T A/T 15 10382 T/T T/T T/C T/T T/T T/T 16 10393 G/G G/G A/G A/G A/G A/A 17 10440 T/T T/T C/T C/T C/T C/C 18 10460 A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A G/A G/A G/A G/G 20 12832 G/A G/G G/G G/G G/G G/G 21 12836 C/C C/C C/C C/T C/C C/C 22 12892 A/A A/A G/A G/A G/G G/G 23 12997 T/T T/T C/T C/T C/T C/C 24 13285 T/T T/T T/T T/C T/T T/T 25 13305 T/T T/T C/T C/T C/T C/C 26 13306 T/C T/T T/T T/T T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G (a)PS = polymorphic site;
• (b)Position of PS in SEQ ID NO:1;
• (c)Haplotype pairs are represented as 1st haplotype/2nd haplotype;
• with alleles of each haplotype # shown 5′ to 3′ as 1st polymorphism/2nd polymorphism in each column.

A method for identifying an association between a trait and at least one haplotype or haplotype pair of the tachykinin receptor 2 (TACR2) gene which comprises comparing the frequency of the haplotype or haplotype pair in a population exhibiting the trait with the frequency of the haplotype or haplotype pair in a reference population, wherein the haplotype is selected from haplotypes 1-29 shown in the table presented immediately below:

• 19 PS PS Haplotype Number(c) (Part 1) No.(a) Position(b) 1 2 3 4 5 6 7 8 9 10 1 1001 A A G G G G G G G G 2 1052 C C C C C C C C C C 3 1147 T T C C C C C C C C 4 1231 T T C C T T T T T T 5 1365 G G G G G G G G G G 6 1416 A A A A A A A A A A 7 1470 T T T T C C C C C C 8 1541 G G G G G G G G G G 9 1873 A G A A A G G G G G 10 10333 C C C C C C C C C C 11 10342 T T T T T T T T T T 12 10368 C C C T T C C T T T 13 10373 G G G G G G G G G T 14 10375 T T T T T T T T T T 15 10382 T T T T T T T T T T 16 10393 G G G G G G G G G G 17 10440 T T T T T T T T T T 18 10460 A A A A A A A A A A 19 12795 A A A A A A A A A A 20 12832 G G G G G A G G G G 21 12836 C T C C C C C C T C 22 12892 A A A A A A A A A A 23 12997 T T T T T T T T T T 24 13285 T C T T T T T T C T 25 13305 T T T T T T T T T T 26 13306 T T T T T C T T T T 27 13371 G G G G G G G G G G PS PS Haplotype Number(c) (Part 2) No.(a) Position(b) 11 12 13 14 15 16 17 18 19 20 1 1001 G G G G G G G G G G 2 1052 C C C C C C C C C C 3 1147 C C C C C C C C T T 4 1231 T T T T T T T T T T 5 1365 G G G G G G G G A G 6 1416 A A A A A A A A A A 7 1470 T T T T T T T T C C 8 1541 G G G G G G G G G A 9 1873 A A A A G G G G G G 10 10333 C C C C C C C C T C 11 10342 T T T T A T T T A A 12 10368 C C C T C C C T C C 13 10373 G G G G G G G G G G 14 10375 T T T T T T T T T A 15 10382 T T T T C T T T T T 16 10393 G G G G G G G G A A 17 10440 T T T T T T T T C C 18 10460 A A A A A A A A A A 19 12795 A A A A A A A A G G 20 12832 A G G G G A G G G G 21 12836 C C C C C C C C C C 22 12892 A A A A A A A A G G 23 12997 T T T T T T T T C C 24 13285 T T T T T T T T T T 25 13305 T T T T T T T T C C 26 13306 C T T T T C T T T T 27 13371 G A G G G G G G G G PS PS Haplotype Number(c) (Part 3) No.(a) Position(b) 21 22 23 24 25 26 27 28 29 1 1001 G G G G G G G G G 2 1052 C C C C C C C T T 3 1147 T T T T T T T C C 4 1231 T T T T T T T T T 5 1365 G G G G G G G G G 6 1416 A A A A A A G A A 7 1470 C C T T T T T C T 8 1541 G G G G G G G G G 9 1873 G G A G G G G G A 10 10333 C C C C C C C C C 11 10342 A T A T T T A A T 12 10368 C T C C C C C C C 13 10373 G G G G G G G G G 14 10375 A T T T T T T T T 15 10382 T T T T T T T T T 16 10393 A G G G G G A A G 17 10440 C T T T T T C C T 18 10460 A A A A A G A A A 19 12795 G A A A A A G G A 20 12832 G G G G G G G G A 21 12836 C C C C T C C C C 22 12892 G A G A A A G G A 23 12997 C T T T T T C C T 24 13285 T T T T C T T T T 25 13305 C T T T T T C C T 26 13306 T T T T T T T T C 27 13371 G G G G G G G G G (a)PS = polymorphic site;
• (b)Position of PS within SEQ ID NO:1;
• (c)Alleles for haplotypes are presented 5′ to 3′ in each column;
• and wherein the haplotype pair is selected from the haplotype pairs shown in the table immediately below:
• 20 PS PS Posi- No. tion Haplotype Pair(c)(Part 1) (a) (b) 7/2 8/4 8/8 8/10 8/14 8/16 8/17 8/18 1 1001 G/A G/G G/G G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 C/T C/C C/C C/C C/C C/C C/C C/C 4 1231 T/T T/C T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 C/T C/T C/C C/C C/T C/T C/T C/T 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 G/G G/A G/G G/G G/A G/G G/G G/G 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/T T/T T/T T/T T/T T/T T/T T/T 12 10368 C/C T/T T/T T/T T/T T/C T/C T/T 13 10373 G/G G/G G/G G/T G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/G G/G G/G G/G 17 10440 T/T T/T T/T T/T T/T T/T T/T T/T 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/A A/A A/A A/A 20 12832 G/G G/G G/G G/G G/G G/A G/G G/G 21 12836 C/T C/C C/C C/C C/C C/C C/C C/C 22 12892 A/A A/A A/A A/A A/A A/A A/A A/A 23 12997 T/T T/T T/T T/T T/T T/T T/T T/T 24 13285 T/C T/T T/T T/T T/T T/T T/T T/T 25 13305 T/T T/T T/T T/T T/T T/T T/T T/T 26 13306 T/T T/T T/T T/T T/T T/C T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 2) (a) (b) 8/20 8/24 8/26 8/28 11/1 11/6 11/8 11/11 1 1001 G/G G/G G/G G/G G/A G/G G/G G/G 2 1052 C/C C/C C/C C/T C/C C/C C/C C/C 3 1147 C/T C/T C/T C/C C/T C/C C/C C/C 4 1231 T/T T/T T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 C/C C/T C/T C/C T/T T/C T/C T/T 8 1541 G/A G/G G/G G/G G/G G/G G/G G/G 9 1873 G/G G/G G/G G/G A/A A/G A/G A/A 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/A T/T T/T T/A T/T T/T T/T T/T 12 10368 T/C T/C T/C T/C C/C C/C C/T C/C 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/A T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/A G/G G/G G/A G/G G/G G/G G/G 17 10440 T/C T/T T/T T/C T/T T/T T/T T/T 18 10460 A/A A/A A/G A/A A/A A/A A/A A/A 19 12795 A/G A/A A/A A/G A/A A/A A/A A/A 20 12832 G/G G/G G/G G/G A/G A/A A/G A/A 21 12836 C/C C/C C/C C/C C/C C/C C/C C/C 22 12892 A/G A/A A/A A/G A/A A/A A/A A/A 23 12997 T/C T/T T/T T/C T/T T/T T/T T/T 24 13285 T/T T/T T/T T/T T/T T/T T/T T/T 25 13305 T/C T/T T/T T/C T/T T/T T/T T/T 26 13306 T/T T/T T/T T/T C/T C/C C/T C/C 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 3) (a) (b) 11/14 11/25 13/1 13/3 13/5 13/7 13/8 13/9 1 1001 G/G G/G G/A G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 c/c C/T C/T C/C C/C C/C C/C C/C 4 1231 T/T T/T T/T T/C T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 T/T T/T T/T T/T T/C T/C T/C T/C 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 A/A A/G A/A A/A A/A A/G A/G A/G 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/T T/T T/T T/T T/T T/T T/T T/T 12 10368 C/T C/C C/C C/C C/T C/C C/T C/T 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/G G/G G/G G/G 17 10440 T/T T/T T/T T/T T/T T/T T/T T/T 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/A A/A A/A A/A 20 12832 A/G A/G G/G G/G G/G G/G G/G G/G 21 12836 C/C C/T C/C C/C C/C C/C C/C C/T 22 12892 A/A A/A A/A A/A A/A A/A A/A A/A 23 12997 T/T T/T T/T T/T T/T T/T T/T T/T 24 13285 T/T T/C T/T T/T T/T T/T T/T T/C 25 13305 T/T T/T T/T T/T T/T T/T T/T T/T 26 13306 C/T C/T T/T T/T T/T T/T T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 4) (a) (b) 13/11 13/12 13/13 13/14 13/19 13/21 13/22 13/27 1 1001 G/G G/G G/G G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 C/C C/C C/C C/C C/T C/T C/T C/T 4 1231 T/T T/T T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/A G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/G 7 1470 T/T T/T T/T T/T T/C T/C T/C T/T 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 A/A A/A A/A A/A A/G A/G A/G A/G 10 10333 C/C C/C C/C C/C C/T C/C C/C C/C 11 10342 T/T T/T T/T T/T T/A T/A T/T T/A 12 10368 C/C C/C C/C C/T C/C C/C C/T C/C 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/A T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/A G/A G/G G/A 17 10440 T/T T/T T/T T/T T/C T/C T/T T/C 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/G A/G A/A A/G 20 12832 G/A G/G G/G G/G G/G G/G G/G G/G 21 12836 C/C C/C C/C C/C C/C C/C C/C C/C 22 12892 A/A A/A A/A A/A A/G A/G A/A A/G 23 12997 T/T T/T T/T T/T T/C T/C T/T T/C 24 13285 T/T T/T T/T T/T T/T T/T T/T T/T 25 13305 T/T T/T T/T T/T T/C T/C T/T T/C 26 13306 T/C T/T T/T T/T T/T T/T T/T T/T 27 13371 G/G G/A G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 5) (a) (b) 13/29 14/14 19/15 19/25 21/23 21/27 1 1001 G/G G/G G/G G/G G/G G/G 2 1052 C/T C/C C/C C/C C/C C/C 3 1147 C/C C/C T/C T/T T/T T/T 4 1231 T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G A/G A/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/G 7 1470 T/T T/T C/T C/T C/T C/T 8 1541 G/G G/G G/G G/G G/G G/G 9 1873 A/A A/A G/G G/G G/A G/G 10 10333 C/C C/C T/C T/C C/C C/C 11 10342 T/T T/T A/A A/T A/A A/A 12 10368 C/C T/T C/C C/C C/C C/C 13 10373 G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T A/T A/T 15 10382 T/T T/T T/C T/T T/T T/T 16 10393 G/G G/G A/G A/G A/G A/A 17 10440 T/T T/T C/T C/T C/T C/C 18 10460 A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A G/A G/A G/A G/G 20 12832 G/A G/G G/G G/G G/G G/G 21 12836 C/C C/C C/C C/T C/C C/C 22 12892 A/A A/A G/A G/A G/G G/G 23 12997 T/T T/T C/T C/T C/T C/C 24 13285 T/T T/T T/T T/C T/T T/T 25 13305 T/T T/T C/T C/T C/T C/C 26 13306 T/C T/T T/T T/T T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G (a)PS = polymorphic site;
• (b)Position of PS in SEQ ID NO:1;
• (c)Haplotype pairs are represented as 1sthaplotype/2nd haplotype;
• with alleles of each haplotype shown 5′ to 3′ as 1st polymorphism/2ndpolymorphism in each column;
• wherein a statistically significant different frequency of the haplotype or haplotype pair in the trait population than in the reference population indicates the trait is associated with the haplotype or haplotype pair.

A method for reducing the potential for bias in a clinical trial of a candidate drug for treating a disease or condition predicted to be associated with TACR2 activity, the method comprising determining which TACR2 haplotype or TACR2 haplotype pair is present in each individual that is participating in the trial;

• and assigning each individual to a treatment group or a control group to produce an equal number of each of the determined TACR2 haplotypes or haplotype pairs in the treatment group and the control group, wherein the TACR2 haplotypes or haplotype pairs are shown in the tables immediately below:
• 21 PS PS Haplotype Number(c) (Part 1) No.(a) Position(b) 1 2 3 4 5 6 7 8 9 10 1 1001 A A G G G G G G G G 2 1052 C C C C C C C C C C 3 1147 T T C C C C C C C C 4 1231 T T C C T T T T T T 5 1365 G G G G G G G G G G 6 1416 A A A A A A A A A A 7 1470 T T T T C C C C C C 8 1541 G G G G G G G G G G 9 1873 A G A A A G G G G G 10 10333 C C C C C C C C C C 11 10342 T T T T T T T T T T 12 10368 C C C T T C C T T T 13 10373 G G G G G G G G G T 14 10375 T T T T T T T T T T 15 10382 T T T T T T T T T T 16 10393 G G G G G G G G G G 17 10440 T T T T T T T T T T 18 10460 A A A A A A A A A A 19 12795 A A A A A A A A A A 20 12832 G G G G G A G G G G 21 12836 C T C C C C C C T C 22 12892 A A A A A A A A A A 23 12997 T T T T T T T T T T 24 13285 T C T T T T T T C T 25 13305 T T T T T T T T T T 26 13306 T T T T T C T T T T 27 13371 G G G G G G G G G G PS PS Haplotype Number(c) (Part 2) No.(a) Position(b) 11 12 13 14 15 16 17 18 19 20 1 1001 G G G G G G G G G G 2 1052 C C C C C C C C C C 3 1147 C C C C C C C C T T 4 1231 T T T T T T T T T T 5 1365 G G G G G G G G A G 6 1416 A A A A A A A A A A 7 1470 T T T T T T T T C C 8 1541 G G G G G G G G G A 9 1873 A A A A G G G G G G 10 10333 C C C C C C C C T C 11 10342 T T T T A T T T A A 12 10368 C C C T C C C T C C 13 10373 G G G G G G G G G G 14 10375 T T T T T T T T T A 15 10382 T T T T C T T T T T 16 10393 G G G G G G G G A A 17 10440 T T T T T T T T C C 18 10460 A A A A A A A A A A 19 12795 A A A A A A A A G G 20 12832 A G G G G A G G G G 21 12836 C C C C C C C C C C 22 12892 A A A A A A A A G G 23 12997 T T T T T T T T C C 24 13285 T T T T T T T T T T 25 13305 T T T T T T T T C C 26 13306 C T T T T C T T T T 27 13371 G A G G G G G G G G PS PS Haplotype Number(c) (Part 3) No.(a) Position(b) 21 22 23 24 25 26 27 28 29 1 1001 G G G G G G G G G 2 1052 C C C C C C C T T 3 1147 T T T T T T T C C 4 1231 T T T T T T T T T 5 1365 G G G G G G G G G 6 1416 A A A A A A G A A 7 1470 C C T T T T T C T 8 1541 G G G G G G G G G 9 1873 G G A G G G G G A 10 10333 C C C C C C C C C 11 10342 A T A T T T A A T 12 10368 C T C C C C C C C 13 10373 G G G G G G G G G 14 10375 A T T T T T T T T 15 10382 T T T T T T T T T 16 10393 A G G G G G A A G 17 10440 C T T T T T C C T 18 10460 A A A A A G A A A 19 12795 G A A A A A G G A 20 12832 G G G G G G G G A 21 12836 C C C C T C C C C 22 12892 G A G A A A G G A 23 12997 C T T T T T C C T 24 13285 T T T T C T T T T 25 13305 C T T T T T C C T 26 13306 T T T T T T T T C 27 13371 G G G G G G G G G (a)PS = polymorphic site;
• (b)Position of PS within SEQ ID NO:1;
• (c)Alleles for haplotypes are presented 5′ to 3′ in each column;
• PS PS Posi- No. tion Haplotype Pair(c)(Part 1) (a) (b) 7/2 8/4 8/8 8/10 8/14 8/16 8/17 8/18 1 1001 G/A G/G G/G G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 C/T C/C C/C C/C C/C C/C C/C C/C 4 1231 T/T T/C T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 C/T C/T C/C C/C C/T C/T C/T C/T 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 G/G G/A G/G G/G G/A G/G G/G G/G 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/T T/T T/T T/T T/T T/T T/T T/T 12 10368 C/C T/T T/T T/T T/T T/C T/C T/T 13 10373 G/G G/G G/G G/T G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/G G/G G/G G/G 17 10440 T/T T/T T/T T/T T/T T/T T/T T/T 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/A A/A A/A A/A 20 12832 G/G G/G G/G G/G G/G G/A G/G G/G 21 12836 C/T C/C C/C C/C C/C C/C C/C C/C 22 12892 A/A A/A A/A A/A A/A A/A A/A A/A 23 12997 T/T T/T T/T T/T T/T T/T T/T T/T 24 13285 T/C T/T T/T T/T T/T T/T T/T T/T 25 13305 T/T T/T T/T T/T T/T T/T T/T T/T 26 13306 T/T T/T T/T T/T T/T T/C T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 2) (a) (b) 8/20 8/24 8/26 8/28 11/1 11/6 11/8 11/11 1 1001 G/G G/G G/G G/G G/A G/G G/G G/G 2 1052 C/C C/C C/C C/T C/C C/C C/C C/C 3 1147 C/T C/T C/T C/C C/T C/C C/C C/C 4 1231 T/T T/T T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 C/C C/T C/T C/C T/T T/C T/C T/T 8 1541 G/A G/G G/G G/G G/G G/G G/G G/G 9 1873 G/G G/G G/G G/G A/A A/G A/G A/A 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/A T/T T/T T/A T/T T/T T/T T/T 12 10368 T/C T/C T/C T/C C/C C/C C/T C/C 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/A T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/A G/G G/G G/A G/G G/G G/G G/G 17 10440 T/C T/T T/T T/C T/T T/T T/T T/T 18 10460 A/A A/A A/G A/A A/A A/A A/A A/A 19 12795 A/G A/A A/A A/G A/A A/A A/A A/A 20 12832 G/G G/G G/G G/G A/G A/A A/G A/A 21 12836 C/C C/C C/C C/C C/C C/C C/C C/C 22 12892 A/G A/A A/A A/G A/A A/A A/A A/A 23 12997 T/C T/T T/T T/C T/T T/T T/T T/T 24 13285 T/T T/T T/T T/T T/T T/T T/T T/T 25 13305 T/C T/T T/T T/C T/T T/T T/T T/T 26 13306 T/T T/T T/T T/T C/T C/C C/T C/C 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 3) (a) (b) 11/14 11/25 13/1 13/3 13/5 13/7 13/8 13/9 1 1001 G/G G/G G/A G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 C/C C/T C/T C/C C/C C/C C/C C/C 4 1231 T/T T/T T/T T/C T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 T/T T/T T/T T/T T/C T/C T/C T/C 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 A/A A/G A/A A/A A/A A/G A/G A/G 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/T T/T T/T T/T T/T T/T T/T T/T 12 10368 C/T C/C C/C C/C C/T C/C C/T C/T 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/G G/G G/G G/G 17 10440 T/T T/T T/T T/T T/T T/T T/T T/T 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/A A/A A/A A/A 20 12832 A/G A/G G/G G/G G/G G/G G/G G/G 21 12836 C/C C/T C/C C/C C/C C/C C/C C/T 22 12892 A/A A/A A/A A/A A/A A/A A/A A/A 23 12997 T/T T/T T/T T/T T/T T/T T/T T/T 24 13285 T/T T/C T/T T/T T/T T/T T/T T/C 25 13305 T/T T/T T/T T/T T/T T/T T/T T/T 26 13306 C/T C/T T/T T/T T/T T/T T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 4) (a) (b) 13/11 13/12 13/13 13/14 13/19 13/21 13/22 13/27 1 1001 G/G G/G G/G G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 C/C C/C C/C C/C C/T C/T C/T C/T 4 1231 T/T T/T T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/A G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/G 7 1470 T/T T/T T/T T/T T/C T/C T/C T/T 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 A/A A/A A/A A/A A/G A/G A/G A/G 10 10333 C/C C/C C/C C/C C/T C/C C/C C/C 11 10342 T/T T/T T/T T/T T/A T/A T/T T/A 12 10368 C/C C/C C/C C/T C/C C/C C/T C/C 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/A T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/A G/A G/G G/A 17 10440 T/T T/T T/T T/T T/C T/C T/T T/C 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/G A/G A/A A/G 20 12832 G/A G/G G/G G/G G/G G/G G/G G/G 21 12836 C/C C/C C/C C/C C/C C/C C/C C/C 22 12892 A/A A/A A/A A/A A/G A/G A/A A/G 23 12997 T/T T/T T/T T/T T/C T/C T/T T/C 24 13285 T/T T/T T/T T/T T/T T/T T/T T/T 25 13305 T/T T/T T/T T/T T/C T/C T/T T/C 26 13306 T/C T/T T/T T/T T/T T/T T/T T/T 27 13371 G/G G/A G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 5) (a) (b) 13/29 14/14 19/15 19/25 21/23 21/27 1 1001 G/G G/G G/G G/G G/G G/G 2 1052 C/T C/C C/C C/C C/C C/C 3 1147 C/C C/C T/C T/T T/T T/T 4 1231 T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G A/G A/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/G 7 1470 T/T T/T C/T C/T C/T C/T 8 1541 G/G G/G G/G G/G G/G G/G 9 1873 A/A A/A G/G G/G G/A G/G 10 10333 C/C C/C T/C T/C C/C C/C 11 10342 T/T T/T A/A A/T A/A A/A 12 10368 C/C T/T C/C C/C C/C C/C 13 10373 G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T A/T A/T 15 10382 T/T T/T T/C T/T T/T T/T 16 10393 G/G G/G A/G A/G A/G A/A 17 10440 T/T T/T C/T C/T C/T C/C 18 10460 A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A G/A G/A G/A G/G 20 12832 G/A G/G G/G G/G G/G G/G 21 12836 C/C C/C C/C C/T C/C C/C 22 12892 A/A A/A G/A G/A G/G G/G 23 12997 T/T T/T C/T C/T C/T C/C 24 13285 T/T T/T T/T T/C T/T T/T 25 13305 T/T T/T C/T C/T C/T C/C 26 13306 T/C T/T T/T T/T T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G (a)PS = polymorphic site;
• (b)Position of PS in SEQ ID NO:1;
• (c)Haplotype pairs are represented as 1sthaplotype/2nd haplotype;
• with alleles of each haplotype shown 5′ to 3′ as 1st polymorphism/2ndpolymorphism in each column.

An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:

• (a) a first nucleotide sequence which comprises a tachykinin receptor 2 (TACR2) isogene, wherein the TACR2 isogene is selected from the group consisting of isogenes 1-12 and 14-29 shown in the table immediately below and wherein each of the isogenes comprises the regions of SEQ ID NO:1 shown in the table immediately below, except where substituted by the corresponding sequence of polymorphisms whose positions and alleles are set forth in the table immediately below;
• and
• 22 PS Isogene Number(d) Region Examined(a) PS No.(b) Position(c) 1 2 3 4 5 6 7 8 9 10 886-1980 1 1001 A A G G G G G G G G 886-1980 2 1052 C C C C C C C C C C 886-1980 3 1147 T T C C C C C C C C 886-1980 4 1231 T T C C T T T T T T 886-1980 5 1365 G G G G G G G G G G 886-1980 6 1416 A A A A A A A A A A 886-1980 7 1470 T T T T C C C C C C 886-1980 8 1541 G G G G G G G G G G 886-1980 9 1873 A G A A A G G G G G 10306-10755 10 10333 C C C C C C C C C C 10306-10755 11 10342 T T T T T T T T T T 10306-10755 12 10368 C C C T T C C T T T 10306-10755 13 10373 G G G G G G G G G T 10306-10755 14 10375 T T T T T T T T T T 10306-10755 15 10382 T T T T T T T T T T 10306-10755 16 10393 G G G G G G G G G G 10306-10755 17 10440 T T T T T T T T T T 10306-10755 18 10460 A A A A A A A A A A 12473-13441 19 12795 A A A A A A A A A A 12473-13441 20 12832 G G G G G A G G G G 12473-13441 21 12836 C T C C C C C C T C 12473-13441 22 12892 A A A A A A A A A A 12473-13441 23 12997 T T T T T T T T T T 12473-13441 24 13285 T C T T T T T T C T 12473-13441 25 13305 T T T T T T T T T T 12473-13441 26 13306 T T T T T C T T T T 12473-13441 27 13371 G G G G G G G G G G PS Isogene Number(d) Region Examined(a) PS No.(b) Position(c) 11 12 14 15 16 17 18 19 20 886-1980 1 1001 G G G G G G G G G 886-1980 2 1052 C C C C C C C C C 886-1980 3 1147 C C C C C C C T T 886-1980 4 1231 T T T T T T T T T 886-1980 5 1365 G G G G G G G A G 886-1980 6 1416 A A A A A A A A A 886-1980 7 1470 T T T T T T T C C 886-1980 8 1541 G G G G G G G G A 886-1980 9 1873 A A A G G G G G G 10306-10755 10 10333 C C C C C C C T C 10306-10755 11 10342 T T T A T T T A A 10306-10755 12 10368 C C T C C C T C C 10306-10755 13 10373 G G G G G G G G G 10306-10755 14 10375 T T T T T T T T A 10306-10755 15 10382 T T T C T T T T T 10306-10755 16 10393 G G G G G G G A A 10306-10755 17 10440 T T T T T T T C C 10306-10755 18 10460 A A A A A A A A A 12473-13441 19 12795 A A A A A A A G G 12473-13441 20 12832 A G G G A G G G G 12473-13441 21 12836 C C C C C C C C C 12473-13441 22 12892 A A A A A A A G G 12473-13441 23 12997 T T T T T T T C C 12473-13441 24 13285 T T T T T T T T T 12473-13441 25 13305 T T T T T T T C C 12473-13441 26 13306 C T T T C T T T T 12473-13441 27 13371 G A G G G G G G G PS Isogene Number(d) Region Examined(a) PS No.(b) Position(c) 21 22 23 24 25 26 27 28 29 886-1980 1 1001 G G G G G G G G G 886-1980 2 1052 C C C C C C C T T 886-1980 3 1147 T T T T T T T C C 886-1980 4 1231 T T T T T T T T T 886-1980 5 1365 G G G G G G G G G 886-1980 6 1416 A A A A A A G A A 886-1980 7 1470 C C T T T T T C T 886-1980 8 1541 G G G G G G G G G 886-1980 9 1873 G G A G G G G G A 10306-10755 10 10333 C C C C C C C C C 10306-10755 11 10342 A T A T T T A A T 10306-10755 12 10368 C T C C C C C C C 10306-10755 13 10373 G G G G G G G G G 10306-10755 14 10375 A T T T T T T T T 10306-10755 15 10382 T T T T T T T T T 10306-10755 16 10393 A G G G G G A A G 10306-10755 17 10440 C T T T T T C C T 10306-10755 18 10460 A A A A A G A A A 12473-13441 19 12795 G A A A A A G G A 12473-13441 20 12832 G G G G G G G G A 12473-13441 21 12836 C C C C T C C C C 12473-13441 22 12892 G A G A A A G G A 12473-13441 23 12997 C T T T T T C C T 12473-13441 24 13285 T T T T C T T T T 12473-13441 25 13305 C T T T T T C C T 12473-13441 26 13306 T T T T T T T T C 12473-13441 27 13371 G G G G G G G G G (a)Region examined represents the nucleotide positions defining the start and stop positions within the 1st SEQ ID NO of the sequenced region;
• (b)PS = polymorphic site;
• (c)Position of PS in SEQ ID NO:1;
• (d)Alleles for isogenes are presented 5′ to 3′ in each column;
• (b) a second nucleotide sequence which is complementary to the first nucleotide sequence.

An isolated fragment of a tachykinin receptor 2 (TACR2) isogene, wherein the fragment comprises at least 10 nucleotides in one of the regions of SEQ ID NO:1 shown in the table immediately below and wherein the fragment comprises one or more polymorphisms selected from the group consisting of adenine at PS1, thymine at PS2, thymine at PS3, cytosine at PS4, adenine at PS5, guanine at PS6, cytosine at PS7, adenine at PS8, guanine at PS9, thymine at PS10, adenine at PS11, thymine at PS12, thymine at PS13, adenine at PS14, cytosine at PS15, adenine at PS16, cytosine at PS17, guanine at PS18, guanine at PS19, adenine at PS20, thymine at PS21, guanine at PS22, cytosine at PS23, cytosine at PS24, cytosine at PS25, cytosine at PS26 and adenine at PS27, wherein the selected polymorphism has the position set forth in the table immediately below:

• 23 PS Isogene Number(d) Region Examined(a) PS No.(b) Position(c) 1 2 3 4 5 6 7 8 9 10 886-1980 1 1001 A A G G G G G G G G 886-1980 2 1052 C C C C C C C C C C 886-1980 3 1147 T T C C C C C C C C 886-1980 4 1231 T T C C T T T T T T 886-1980 5 1365 G G G G G G G G G G 886-1980 6 1416 A A A A A A A A A A 886-1980 7 1470 T T T T C C C C C C 886-1980 8 1541 G G G G G G G G G G 886-1980 9 1873 A G A A A G G G G G 10306-10755 10 10333 C C C C C C C C C C 10306-10755 11 10342 T T T T T T T T T T 10306-10755 12 10368 C C C T T C C T T T 10306-10755 13 10373 G G G G G G G G G T 10306-10755 14 10375 T T T T T T T T T T 10306-10755 15 10382 T T T T T T T T T T 10306-10755 16 10393 G G G G G G G G G G 10306-10755 17 10440 T T T T T T T T T T 10306-10755 18 10460 A A A A A A A A A A 12473-13441 19 12795 A A A A A A A A A A 12473-13441 20 12832 G G G G G A G G G G 12473-13441 21 12836 C T C C C C C C T C 12473-13441 22 12892 A A A A A A A A A A 12473-13441 23 12997 T T T T T T T T T T 12473-13441 24 13285 T C T T T T T T C T 12473-13441 25 13305 T T T T T T T T T T 12473-13441 26 13306 T T T T T C T T T T 12473-13441 27 13371 G G G G G G G G G G PS Isogene Number(d) Region Examined(a) PS No.(b) Position(c) 11 12 14 15 16 17 18 19 20 886-1980 1 1001 G G G G G G G G G 886-1980 2 1052 C C C C C C C C C 886-1980 3 1147 C C C C C C C T T 886-1980 4 1231 T T T T T T T T T 886-1980 5 1365 G G G G G G G A G 886-1980 6 1416 A A A A A A A A A 886-1980 7 1470 T T T T T T T C C 886-1980 8 1541 G G G G G G G G A 886-1980 9 1873 A A A G G G G G G 10306-10755 10 10333 C C C C C C C T C 10306-10755 11 10342 T T T A T T T A A 10306-10755 12 10368 C C T C C C T C C 10306-10755 13 10373 G G G G G G G G G 10306-10755 14 10375 T T T T T T T T A 10306-10755 15 10382 T T T C T T T T T 10306-10755 16 10393 G G G G G G G A A 10306-10755 17 10440 T T T T T T T C C 10306-10755 18 10460 A A A A A A A A A 12473-13441 19 12795 A A A A A A A G G 12473-13441 20 12832 A G G G A G G G G 12473-13441 21 12836 C C C C C C C C C 12473-13441 22 12892 A A A A A A A G G 12473-13441 23 12997 T T T T T T T C C 12473-13441 24 13285 T T T T T T T T T 12473-13441 25 13305 T T T T T T T C C 12473-13441 26 13306 C T T T C T T T T 12473-13441 27 13371 G A G G G G G G G PS Isogene Number(d) Region Examined(a) PS No.(b) Position(c) 21 22 23 24 25 26 27 28 29 886-1980 1 1001 G G G G G G G G G 886-1980 2 1052 C C C C C C C T T 886-1980 3 1147 T T T T T T T C C 886-1980 4 1231 T T T T T T T T T 886-1980 5 1365 G G G G G G G G G 886-1980 6 1416 A A A A A A G A A 886-1980 7 1470 C C T T T T T C T 886-1980 8 1541 G G G G G G G G G 886-1980 9 1873 G G A G G G G G A 10306-10755 10 10333 C C C C C C C C C 10306-10755 11 10342 A T A T T T A A T 10306-10755 12 10368 C T C C C C C C C 10306-10755 13 10373 G G G G G G G G G 10306-10755 14 10375 A T T T T T T T T 10306-10755 15 10382 T T T T T T T T T 10306-10755 16 10393 A G G G G G A A G 10306-10755 17 10440 C T T T T T C C T 10306-10755 18 10460 A A A A A G A A A 12473-13441 19 12795 G A A A A A G G A 12473-13441 20 12832 G G G G G G G G A 12473-13441 21 12836 C C C C T C C C C 12473-13441 22 12892 G A G A A A G G A 12473-13441 23 12997 C T T T T T C C T 12473-13441 24 13285 T T T T C T T T T 12473-13441 25 13305 C T T T T T C C T 12473-13441 26 13306 T T T T T T T T C 12473-13441 27 13371 G G G G G G G G G (a)Region examined represents the nucleotide positions defining the start and stop positions within SEQ ID NO:1 of the regions sequenced;
• (b)PS = polymorphic site;
• (c)Position of PS within SEQ ID NO:1;
• (d)Alleles for TACR2 isogenes are presented 5′ to 3′ in each column.

An isolated polynucleotide comprising a coding sequence variant for a TACR2 isogene, wherein the coding sequence variant is selected from the group consisting of A-J represented in the table below and wherein the selected coding sequence variant comprises the regions of SEQ ID NO:2 shown in the table below, except where substituted by the corresponding sequence of polymorphisms whose positions and alleles are set forth in the table immediately below:

• 24 PS PS Coding Sequence Variants(d) Region Examined(a) No.(b) Position(c) A B C D E F G H I J 1-391 6 14 A A A A A A A A A G 1-391 7 68 T C C C T C C T T T 1-391 8 139 G G G G G G A G G G 742-1197 18 751 A A A A A A A A G A 742-1197 19 1087 A A A A A G G A A G 742-1197 20 1124 G G A G A G G G G G 742-1197 21 1128 T C C T C C C C C C 742-1197 22 1184 A A A A A G G G A G (a)Region examined represents the nucleotide positions defining the start and stop positions within SEQ ID NO:2 of the regions sequenced;
• (b)PS = polymorphic site;
• (c)Position of PS in SEQ ID NO:2;
• (d)Alleles for the coding sequence variants are presented 5′ to 3′ in each column.

A method for validating the TACR2 protein as a candidate target for treating a medical condition predicted to be associated with TACR2 activity, the method comprising:

• (a) comparing the frequency of each of the TACR2 haplotypes in the table shown immediately below between first and second populations, wherein the first population is a group of individuals having the medical condition and the second population is a group of individuals lacking the medical condition;
• and
• (b) making a decision whether to pursue TACR2 as a target for treating the medical condition;
• wherein if at least one of the TACR2 haplotypes is present in a frequency in the first population that is different from the frequency in the second population at a statistically significant level, then the decision is to pursue the TACR2 protein as a target and if none of the TACR2 haplotypes are seen in a different frequency, at a statistically significant level, between the first and second populations, then the decision is to not pursue the TACR2 protein as a target
• 26 PS PS Posi- No. tion Haplotype Number(c) (Part 1) (a) (b) 1 2 3 4 5 6 7 8 9 10 1 1001 A A G G G G G G G G 2 1052 C C C C C C C C C C 3 1147 T T C C C C C C C C 4 1231 T T C C T T T T T T 5 1365 G G G G G G G G G G 6 1416 A A A A A A A A A A 7 1470 T T T T C C C C C C 8 1541 G G G G G G G G G G 9 1873 A G A A A G G G G G 10 10333 C C C C C C C C C C 11 10342 T T T T T T T T T T 12 10368 C C C T T C C T T T 13 10373 G G G G G G G G G T 14 10375 T T T T T T T T T T 15 10382 T T T T T T T T T T 16 10393 G G G G G G G G G G 17 10440 T T T T T T T T T T 18 10460 A A A A A A A A A A 19 12795 A A A A A A A A A A 20 12832 G G G G G A G G G G 21 12836 C T C C C C C C T C 22 12892 A A A A A A A A A A 23 12997 T T T T T T T T T T 24 13285 T C T T T T T T C T 25 13305 T T T T T T T T T T 26 13306 T T T T T C T T T T 27 13371 G G G G G G G G G G PS PS Posi- No. tion Haplotype Number(c) (Part 2) (a) (b) 11 12 13 14 15 16 17 18 19 20 1 1001 G G G G G G G G G G 2 1052 C C C C C C C C C C 3 1147 C C C C C C C C T T 4 1231 T T T T T T T T T T 5 1365 G G G G G G G G A G 6 1416 A A A A A A A A A A 7 1470 T T T T T T T T C C 8 1541 G G G G G G G G G A 9 1873 A A A A G G G G G G 10 10333 C C C C C C C C T C 11 10342 T T T T A T T T A A 12 10368 C C C T C C C T C C 13 10373 G G G G G G G G G G 14 10375 T T T T T T T T T A 15 10382 T T T T C T T T T T 16 10393 G G G G G G G G A A 17 10440 T T T T T T T T C C 18 10460 A A A A A A A A A A 19 12795 A A A A A A A A G G 20 12832 A G G G G A G G G G 21 12836 C C C C C C C C C C 22 12892 A A A A A A A A G G 23 12997 T T T T T T T T C C 24 13285 T T T T T T T T T T 25 13305 T T T T T T T T C C 26 13306 C T T T T C T T T T 27 13371 G A G G G G G G G G PS PS Posi- No. tion Haplotype Number(c) (Part 3) (a) (b) 21 22 23 24 25 26 27 28 29 1 1001 G G G G G G G G G 2 1052 C C C C C C C T T 3 1147 T T T T T T T C C 4 1231 T T T T T T T T T 5 1365 G G G G G G G G G 6 1416 A A A A A A G A A 7 1470 C C T T T T T C T 8 1541 G G G G G G G G G 9 1873 G G A G G G G G A 10 10333 C C C C C C C C C 11 10342 A T A T T T A A T 12 10368 C T C C C C C C C 13 10373 G G G G G G G G G 14 10375 A T T T T T T T T 15 10382 T T T T T T T T T 16 10393 A G G G G G A A G 17 10440 C T T T T T C C T 18 10460 A A A A A G A A A 19 12795 G A A A A A G G A 20 12832 G G G G G G G G A 21 12836 C C C C T C C C C 22 12892 G A G A A A G G A 23 12997 C T T T T T C C T 24 13285 T T T T C T T T T 25 13305 C T T T T T C C T 26 13306 T T T T T T T T C 27 13371 G G G G G G G G G (a)PS = polymorphic site;
• (b)Position of PS within SEQ ID NO:1;
• (c)Alleles for haplotypes are presented 5′ to 3′ in each column.

A computer system for storing and analyzing polymorphism data for the tachykinin receptor 2 gene, comprising:

• (a) a central processing unit (CPU);
• (b) a communication interface;
• (c) a display device;
• (d) an input device;
• and
• (e) a database containing the polymorphism data;
• wherein the polymorphism data comprises the haplotypes set forth in the table immediately below:
• 27 PS PS Haplotype Number(c) (Part 1) No.(a) Position(b) 1 2 3 4 5 6 7 8 9 10 1 1001 A A G G G G G G G G 2 1052 C C C C C C C C C C 3 1147 T T C C C C C C C C 4 1231 T T C C T T T T T T 5 1365 G G G G G G G G G G 6 1416 A A A A A A A A A A 7 1470 T T T T C C C C C C 8 1541 G G G G G G G G G G 9 1873 A G A A A G G G G G 10 10333 C C C C C C C C C C 11 10342 T T T T T T T T T T 12 10368 C C C T T C C T T T 13 10373 G G G G G G G G G T 14 10375 T T T T T T T T T T 15 10382 T T T T T T T T T T 16 10393 G G G G G G G G G G 17 10440 T T T T T T T T T T 18 10460 A A A A A A A A A A 19 12795 A A A A A A A A A A 20 12832 G G G G G A G G G G 21 12836 C T C C C C C C T C 22 12892 A A A A A A A A A A 23 12997 T T T T T T T T T T 24 13285 T C T T T T T T C T 25 13305 T T T T T T T T T T 26 13306 T T T T T C T T T T 27 13371 G G G G G G G G G G PS PS Haplotype Number(c) (Part 2) No.(a) Position(b) 11 12 13 14 15 16 17 18 19 20 1 1001 G G G G G G G G G G 2 1052 C C C C C C C C C C 3 1147 C C C C C C C C T T 4 1231 T T T T T T T T T T 5 1365 G G G G G G G G A G 6 1416 A A A A A A A A A A 7 1470 T T T T T T T T C C 8 1541 G G G G G G G G G A 9 1873 A A A A G G G G G G 10 10333 C C C C C C C C T C 11 10342 T T T T A T T T A A 12 10368 C C C T C C C T C C 13 10373 G G G G G G G G G G 14 10375 T T T T T T T T T A 15 10382 T T T T C T T T T T 16 10393 G G G G G G G G A A 17 10440 T T T T T T T T C C 18 10460 A A A A A A A A A A 19 12795 A A A A A A A A G G 20 12832 A G G G G A G G G G 21 12836 C C C C C C C C C C 22 12892 A A A A A A A A G G 23 12997 T T T T T T T T C C 24 13285 T T T T T T T T T T 25 13305 T T T T T T T T C C 26 13306 C T T T T C T T T T 27 13371 G A G G G G G G G G PS PS Haplotype Number(c) (Part 3) No.(a) Position(b) 21 22 23 24 25 26 27 28 29 1 1001 G G G G G G G G G 2 1052 C C C C C C C T T 3 1147 T T T T T T T C C 4 1231 T T T T T T T T T 5 1365 G G G G G G G G G 6 1416 A A A A A A G A A 7 1470 C C T T T T T C T 8 1541 G G G G G G G G G 9 1873 G G A G G G G G A 10 10333 C C C C C C C C C 11 10342 A T A T T T A A T 12 10368 C T C C C C C C C 13 10373 G G G G G G G G G 14 10375 A T T T T T T T T 15 10382 T T T T T T T T T 16 10393 A G G G G G A A G 17 10440 C T T T T T C C T 18 10460 A A A A A G A A A 19 12795 G A A A A A G G A 20 12832 G G G G G G G G A 21 12836 C C C C T C C C C 22 12892 G A G A A A G G A 23 12997 C T T T T T C C T 24 13285 T T T T C T T T T 25 13305 C T T T T T C C T 26 13306 T T T T T T T T C 27 13371 G G G G G G G G G (a)PS = polymorphic site;
• (b)Position of PS within SEQ ID NO:1;
• (c)Alleles for haplotypes are presented 5′ to 3′ in each column;
• the haplotype pairs set forth in the table immediately below:
• 28 PS PS Posi- No. tion Haplotype Pair(c)(Part 1) (a) (b) 7/2 8/4 8/8 8/10 8/14 8/16 8/17 8/18 1 1001 G/A G/G G/G G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 C/T C/C C/C C/C C/C C/C C/C C/C 4 1231 T/T T/C T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 C/T C/T C/C C/C C/T C/T C/T C/T 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 G/G G/A G/G G/G G/A G/G G/G G/G 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/T T/T T/T T/T T/T T/T T/T T/T 12 10368 C/C T/T T/T T/T T/T T/C T/C T/T 13 10373 G/G G/G G/G G/T G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/G G/G G/G G/G 17 10440 T/T T/T T/T T/T T/T T/T T/T T/T 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/A A/A A/A A/A 20 12832 G/G G/G G/G G/G G/G G/A G/G G/G 21 12836 C/T C/C C/C C/C C/C C/C C/C C/C 22 12892 A/A A/A A/A A/A A/A A/A A/A A/A 23 12997 T/T T/T T/T T/T T/T T/T T/T T/T 24 13285 T/C T/T T/T T/T T/T T/T T/T T/T 25 13305 T/T T/T T/T T/T T/T T/T T/T T/T 26 13306 T/T T/T T/T T/T T/T T/C T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 2) (a) (b) 8/20 8/24 8/26 8/28 11/1 11/6 11/8 11/11 1 1001 G/G G/G G/G G/G G/A G/G G/G G/G 2 1052 C/C C/C C/C C/T C/C C/C C/C C/C 3 1147 C/T C/T C/T C/C C/T C/C C/C C/C 4 1231 T/T T/T T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 C/C C/T C/T C/C T/T T/C T/C T/T 8 1541 G/A G/G G/G G/G G/G G/G G/G G/G 9 1873 G/G G/G G/G G/G A/A A/G A/G A/A 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/A T/T T/T T/A T/T T/T T/T T/T 12 10368 T/C T/C T/C T/C C/C C/C C/T C/C 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/A T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/A G/G G/G G/A G/G G/G G/G G/G 17 10440 T/C T/T T/T T/C T/T T/T T/T T/T 18 10460 A/A A/A A/G A/A A/A A/A A/A A/A 19 12795 A/G A/A A/A A/G A/A A/A A/A A/A 20 12832 G/G G/G G/G G/G A/G A/A A/G A/A 21 12836 C/C C/C C/C C/C C/C C/C C/C C/C 22 12892 A/G A/A A/A A/G A/A A/A A/A A/A 23 12997 T/C T/T T/T T/C T/T T/T T/T T/T 24 13285 T/T T/T T/T T/T T/T T/T T/T T/T 25 13305 T/C T/T T/T T/C T/T T/T T/T T/T 26 13306 T/T T/T T/T T/T C/T C/C C/T C/C 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 3) (a) (b) 11/14 11/25 13/1 13/3 13/5 13/7 13/8 13/9 1 1001 G/G G/G G/A G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 c/c C/T C/T C/C C/C C/C C/C C/C 4 1231 T/T T/T T/T T/C T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/G G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/A 7 1470 T/T T/T T/T T/T T/C T/C T/C T/C 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 A/A A/G A/A A/A A/A A/G A/G A/G 10 10333 C/C C/C C/C C/C C/C C/C C/C C/C 11 10342 T/T T/T T/T T/T T/T T/T T/T T/T 12 10368 C/T C/C C/C C/C C/T C/C C/T C/T 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/T T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/G G/G G/G G/G 17 10440 T/T T/T T/T T/T T/T T/T T/T T/T 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/A A/A A/A A/A 20 12832 A/G A/G G/G G/G G/G G/G G/G G/G 21 12836 C/C C/T C/C C/C C/C C/C C/C C/T 22 12892 A/A A/A A/A A/A A/A A/A A/A A/A 23 12997 T/T T/T T/T T/T T/T T/T T/T T/T 24 13285 T/T T/C T/T T/T T/T T/T T/T T/C 25 13305 T/T T/T T/T T/T T/T T/T T/T T/T 26 13306 C/T C/T. T/T T/T T/T T/T T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 4) (a) (b) 13/11 13/12 13/13 13/14 13/19 13/21 13/22 13/27 1 1001 G/G G/G G/G G/G G/G G/G G/G G/G 2 1052 C/C C/C C/C C/C C/C C/C C/C C/C 3 1147 c/c C/C C/C C/C C/T C/T C/T C/T 4 1231 T/T T/T T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G G/G G/G G/A G/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/A A/A A/G 7 1470 T/T T/T T/T T/T T/C T/C T/C T/T 8 1541 G/G G/G G/G G/G G/G G/G G/G G/G 9 1873 A/A A/A A/A A/A A/G A/G A/G A/G 10 10333 C/C C/C C/C C/C C/T C/C C/C C/C 11 10342 T/T T/T T/T T/T T/A T/A T/T T/A 12 10368 C/C C/C C/C C/T C/C C/C C/T C/C 13 10373 G/G G/G G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T T/T T/A T/T T/T 15 10382 T/T T/T T/T T/T T/T T/T T/T T/T 16 10393 G/G G/G G/G G/G G/A G/A G/G G/A 17 10440 T/T T/T T/T T/T T/C T/C T/T T/C 18 10460 A/A A/A A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A A/A A/A A/G A/G A/A A/G 20 12832 G/A G/G G/G G/G G/G G/G G/G G/G 21 12836 C/C C/C C/C C/C C/C C/C C/C C/C 22 12892 A/A A/A A/A A/A A/G A/G A/A A/G 23 12997 T/T T/T T/T T/T T/C T/C T/T T/C 24 13285 T/T T/T T/T T/T T/T T/T T/T T/T 25 13305 T/T T/T T/T T/T T/C T/C T/T T/C 26 13306 T/C T/T T/T T/T T/T T/T T/T T/T 27 13371 G/G G/A G/G G/G G/G G/G G/G G/G PS PS Posi- No. tion Haplotype Pair(c)(Part 5) (a) (b) 13/29 14/14 19/15 19/25 21/23 21/27 1 1001 G/G G/G G/G G/G G/G G/G 2 1052 C/T C/C C/C C/C C/C C/C 3 1147 C/C C/C T/C T/T T/T T/T 4 1231 T/T T/T T/T T/T T/T T/T 5 1365 G/G G/G A/G A/G G/G G/G 6 1416 A/A A/A A/A A/A A/A A/G 7 1470 T/T T/T C/T C/T C/T C/T 8 1541 G/G G/G G/G G/G G/G G/G 9 1873 A/A A/A G/G G/G G/A G/G 10 10333 C/C C/C T/C T/C C/C C/C 11 10342 T/T T/T A/A A/T A/A A/A 12 10368 C/C T/T C/C C/C C/C C/C 13 10373 G/G G/G G/G G/G G/G G/G 14 10375 T/T T/T T/T T/T A/T A/T 15 10382 T/T T/T T/C T/T T/T T/T 16 10393 G/G G/G A/G A/G A/G A/A 17 10440 T/T T/T C/T C/T C/T C/C 18 10460 A/A A/A A/A A/A A/A A/A 19 12795 A/A A/A G/A G/A G/A G/G 20 12832 G/A G/G G/G G/G G/G G/G 21 12836 C/C C/C C/C C/T C/C C/C 22 12892 A/A A/A G/A G/A G/G G/G 23 12997 T/T T/T C/T C/T C/T C/C 24 13285 T/T T/T T/T T/C T/T T/T 25 13305 T/T T/T C/T C/T C/T C/C 26 13306 T/C T/T T/T T/T T/T T/T 27 13371 G/G G/G G/G G/G G/G G/G (a)PS = polymorphic site;
• (b)Position of PS in SEQ ID NO:1;
• (c)Haplotype pairs are represented as 1st haplotype/2nd haplotype;
• with alleles of each haplotype shown 5′ to 3′ as 1st polymorphism/2nd polymorphism in each column;
• or the frequency data in Tables 5 and 6.

A genome anthology for the tachykinin receptor 2 (TACR2) gene which comprises two or more TACR2 isogenes selected from the group consisting of isogenes 1-29 shown in the table immediately below, and wherein each of the isogenes comprises the regions of SEQ ID NO:1 shown in the table immediately below and wherein each of the isogenes 1-29 is further defined by the corresponding sequence of polymorphisms whose positions and alleles are set forth in the table immediately below:

• 29 PS Isogene Number(d) Region Examined(a) PS No.(b) Position(c) 1 2 3 4 5 6 7 8 9 10 886-1980 1 1001 A A G G G G G G G G 886-1980 2 1052 C C C C C C C C C C 886-1980 3 1147 T T C C C C C C C C 886-1980 4 1231 T T C C T T T T T T 886-1980 5 1365 G G G G G G G G G G 886-1980 6 1416 A A A A A A A A A A 886-1980 7 1470 T T T T C C C C C C 886-1980 8 1541 G G G G G G G G G G 886-1980 9 1873 A G A A A G G G G G 10306-10755 10 10333 C C C C C C C C C C 10306-10755 11 10342 T T T T T T T T T T 10306-10755 12 10368 C C C T T C C T T T 10306-10755 13 10373 G G G G G G G G G T 10306-10755 14 10375 T T T T T T T T T T 10306-10755 15 10382 T T T T T T T T T T 10306-10755 16 10393 G G G G G G G G G G 10306-10755 17 10440 T T T T T T T T T T 10306-10755 18 10460 A A A A A A A A A A 12473-13441 19 12795 A A A A A A A A A A 12473-13441 20 12832 G G G G G A G G G G 12473-13441 21 12836 C T C C C C C C T C 12473-13441 22 12892 A A A A A A A A A A 12473-13441 23 12997 T T T T T T T T T T 12473-13441 24 13285 T C T T T T T T C T 12473-13441 25 13305 T T T T T T T T T T 12473-13441 26 13306 T T T T T C T T T T 12473-13441 27 13371 G G G G G G G G G G PS Isogene Number(d) Region Examined(a) PS No.(b) Position(c) 11 12 13 14 15 16 17 18 19 20 886-1980 1 1001 G G G G G G G G G G 886-1980 2 1052 C C C C C C C C C C 886-1980 3 1147 C C C C C C C C T T 886-1980 4 1231 T T T T T T T T T T 886-1980 5 1365 G G G G G G G G A G 886-1980 6 1416 A A A A A A A A A A 886-1980 7 1470 T T T T T T T T C C 886-1980 8 1541 G G G G G G G G G A 886-1980 9 1873 A A A A G G G G G G 10306-10755 10 10333 C C C C C C C C T C 10306-10755 11 10342 T T T T A T T T A A 10306-10755 12 10368 C C C T C C C T C C 10306-10755 13 10373 G G G G G G G G G G 10306-10755 14 10375 T T T T T T T T T A 10306-10755 15 10382 T T T T C T T T T T 10306-10755 16 10393 G G G G G G G G A A 10306-10755 17 10440 T T T T T T T T C C 10306-10755 18 10460 A A A A A A A A A A 12473-13441 19 12795 A A A A A A A A G G 12473-13441 20 12832 A G G G G A G G G G 12473-13441 21 12836 C C C C C C C C C C 12473-13441 22 12892 A A A A A A A A G G 12473-13441 23 12997 T T T T T T T T C C 12473-13441 24 13285 T T T T T T T T T T 12473-13441 25 13305 T T T T T T T T C C 12473-13441 26 13306 C T T T T C T T T T 12473-13441 27 13371 G A G G G G G G G G PS Isogene Number(d) Region Examined(a) PS No.(b) Position(c) 21 22 23 24 25 26 27 28 29 886-1980 1 1001 G G G G G G G G G 886-1980 2 1052 C C C C C C C T T 886-1980 3 1147 T T T T T T T C C 886-1980 4 1231 T T T T T T T T T 886-1980 5 1365 G G G G G G G G G 886-1980 6 1416 A A A A A A G A A 886-1980 7 1470 C C T T T T T C T 886-1980 8 1541 G G G G G G G G G 886-1980 9 1873 G G A G G G G G A 10306-10755 10 10333 C C C C C C C C C 10306-10755 11 10342 A T A T T T A A T 10306-10755 12 10368 C T C C C C C C C 10306-10755 13 10373 G G G G G G G G G 10306-10755 14 10375 A T T T T T T T T 10306-10755 15 10382 T T T T T T T T T 10306-10755 16 10393 A G G G G G A A G 10306-10755 17 10440 C T T T T T C C T 10306-10755 18 10460 A A A A A G A A A 12473-13441 19 12795 G A A A A A G G A 12473-13441 20 12832 G G G G G G G G A 12473-13441 21 12836 C C C C T C C C C 12473-13441 22 12892 G A G A A A G G A 12473-13441 23 12997 C T T T T T C C T 12473-13441 24 13285 T T T T C T T T T 12473-13441 25 13305 C T T T T T C C T 12473-13441 26 13306 T T T T T T T T C 12473-13441 27 13371 G G G G G G G G G (a)Region examined represents the nucleotide positions defining the start and stop positions within SEQ ID NO:1 of the regions sequenced;
• (b)PS = polymorphic site;
• (c)Position of PS within SEQ ID NO:1;
• (d)Alleles for TACR2 isogenes are presented 5′ to 3′ in each column.