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OwnerRichard A. Shimkets, Elma Fernandes +6inventors
InventorsRichard A. Shimkets, Elma Fernandes, John L. Herrmann, Xiaohong Liu, Meijia Yang, Ferenc L. Boldog, Glennda Smithson, Luca Rastelli
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The invention provides polypeptides, designated herein as POLYX polypeptides, as well as polynucleotides encoding POLYX polypeptides, and antibodies that immunospecifically-bind to POLYX polypeptide or polynucleotide, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which the POLYX polypeptide, polynucleotide, and antibody are used in the detection, prevention, and treatment of a broad range of pathological states.
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:
An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:
The use of a therapeutic in the manufacture of a medicament for treating a syndrome associated with a human disease, the disease selected from a POLYX-associated disorder, wherein said therapeutic is selected from the group consisting of a POLYX polypeptide, a POLYX nucleic acid, and a POLYX antibody.
A method of treating a pathological state in a mammal, the method comprising administering to the mammal a polypeptide in an amount that is sufficient to alleviate the pathological state, wherein the polypeptide is a polypeptide having an amino acid sequence at least 95% identical to a polypeptide comprising an amino acid sequence of at least one of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26, or a biologically active fragment thereof.
Dependencies are inferred from the claim text.