US 2003/0198953 A1Published application

Novel proteins and nucleic acids encoding same

OwnerKimberly A. Spytek, Kumud Majumder +9inventors

InventorsKimberly A. Spytek, Kumud Majumder, Velizar T. Tchernev, Vishnu Mishra, Muralidhara Padigaru, Steven K. Spaderna, Suresh G. Shenoy, Luca Rastelli, Li Li, Raymond J. Taupier, Esha Gangolli

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Abstract

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Claims49

Dependent claims

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, and 34;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, and 34, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, and 34;
and
(d) a variant of an amino acid sequence selected from the group consisting of SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, and 34, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence.

2 more elements

An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, and 34;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, and 35, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting of SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, and 34;
(d) a variant of an amino acid sequence selected from the group consisting SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, and 34, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
(e) a nucleic acid fragment encoding at least a portion of a polypeptide comprising an amino acid sequence chosen from the group consisting of SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, and 34, or a variant of said polypeptide, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
and
(f) a nucleic acid molecule comprising the complement of (a), (b), (c), (d) or (e).

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 09/863,776Filed 23 May 2001
Priority: 30 Mar 2000
Published: 23 Oct 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification27 codes

C12N 9/1205
Transferring phosphorus containing groups, e.g. kinases: phosphotransferases with an alcohol group as acceptor , e.g. protein kinases
A61P 1/14
Drugs for disorders of the alimentary tract or the digestive system: prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics,…
A61P 3/00
Drugs for disorders of the metabolism
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents

Family

Application09/540,763Continuation in part · filed 30 Mar 2000
Application60/206,679Us provisional application · filed 24 May 2000
Application60/206,688Us provisional application · filed 24 May 2000
Application60/206,829Us provisional application · filed 24 May 2000
Application60/207,748Us provisional application · filed 30 May 2000
Application60/207,798Us provisional application · filed 30 May 2000
Application60/208,263Us provisional application · filed 31 May 2000
Application60/208,831Us provisional application · filed 2 Jun 2000
Application60/209,451Us provisional application · filed 5 Jun 2000
Application60/210,060Us provisional application · filed 7 Jun 2000
Application60/219,507Us provisional application · filed 20 Jul 2000
Application60/221,337Us provisional application · filed 26 Jul 2000
Application60/221,927Us provisional application · filed 31 Jul 2000
Application60/263,135Us provisional application · filed 19 Jan 2001
Application60/263,688Us provisional application · filed 24 Jan 2001
Application60/263,694Us provisional application · filed 24 Jan 2001
Application09/863,776Continuation in part · filed 23 May 2001
US 2003/0198953 A1This patent

From the US filing history. Foreign family members aren’t listed.