Silane copolymer compositions containing active agents

#The invention relates generally to biocompatible, hydrophilic compositions, their manufacture, and their use for coating surfaces, such as silicone, glass, and other difficult to coat surfaces. More specifically, the invention relates to hydrophilic coatings which are elastic when dry and resist wet abrasion, and to their use as coatings for articles, such as medical devices, particularly articles composed of polydimethylsiloxane (silicone) rubber.

#Further, the present invention relates to compositions containing an active agent, their manufacture, and their use. Such compositions are useful, for example, as antimicrobials, pharmaceuticals, diagnostic agents, herbicides, insecticides, antifoulants, and the like.

#In the practice of medicine there are many diagnostic and therapeutic procedures which require the insertion of a medical device into the human body through an orifice or tissue or contact of a medical device with blood or tissue. Such devices include guidewires; catheters, including Foley, angioplasty, diagnostic, and balloon catheters; implant devices; contact lenses; IUDs; peristaltic pump chambers; endotracheal tubes; gastroenteric feed tubes; arteriovenous shunts; condoms; and oxygenator and kidney membranes. It is necessary for the surface of these medical devices to have a low coefficient of friction to prevent injury, irritation, or inflammation to the patient and to facilitate medical and surgical procedures.

#Preparation of polyethylene glycol

#To a glass jar was added 200 g of polyethylene glycol (PEG) 1450 (Union Carbide) followed by the addition of 50 g molecular sieves. The jar was then placed in a vacuum oven at 68° C. for 72 hours under full vacuum. The water content of the PEG was then analyzed by Karl Fischer titration and determined to be 454 ppm.

#Preparation of urethane prepolymer