Microbial inhibitory compositions
OwnerGerd Pia Carola Holmstrom, Staffan Kjellberginventors
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Abstract
The present invention provides an antimicrobial composition. The composition comprises a cell-permeabilising agent and at least one compound of general formula (I) wherein R1 and R2 are independently H, halogen, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more heteroatoms, straight chain or branched chain, hydrophilic fluorophilic; R3 and R4 are independently H, halogen, alkyl, aryl or arylalkyl, alkoxy; R3 or R4+R2 can be saturated or an unsaturated cycloalkane; and “” represents a single bond or a double bond provided that at least one of R1, R2, R3 and R4 is a halogen. 1
Claims46
An antimicrobial composition, the composition comprising a cell-permeabilising agent and at least one compound of general formula I:
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- wherein R1 and R2 are independently H, halogen, alky, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more heteroatoms, straight chain or branched chain, hydrophilic or fluorophilic;
- R3 and R4 are independently H, halogen, alkyl, aryl or arylalkyl, alkoxy;
- R3 or R4+R2 can be a saturated or an unsaturated cycloalkane;
- and “” represents a single bond or a double bond provided that at least one of R1, R2, R3 and R4 is halogen.
A method of manufacturing an antimicrobial composition, the method comprising combining a cell-permeabilising agent with and a pharmaceutically acceptable diluent with at least one compound of general formula I:
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- wherein R1 and R2 are independently H, halogen, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more heteroatoms, straight chain or branched chain, hydrophilic or fluorophilic;
- R3 and R4 are independently H, halogen, alkyl, aryl or arylalkyl, alkoxy;
- R3 or R4+R2 can be a saturated or an unsaturated cycloalkane;
- and “” represents a single bond or a double bond provided that at least one of R1, R2, R3 and R4 is halogen;
A method of treating Pseudomonas infection in an animal, the method comprising administering to an animal in need of such treatment a composition comprising tobramycin and at least one compound of general formula I:
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- wherein R1 and R2 are independently H, halogen, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more heteroatoms, straight chain or branched chain, hydrophilic or fluorophilic;
- R3 and R4 are independently H, halogen, alkyl, aryl or arylalkyl, alkoxy;
- R3 or R4+R2 can be a saturated or an unsaturated cycloalkane;
- and “” represents a single bond or a double bond provided that at least one of R1, R2, R3 and R4 is halogen.
A composition for use in treatment of Pseudomonas infection, the composition comprising tobramycin and at least one compound of general formula I:
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- wherein R1 and R2 are independently H, halogen, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more heteroatoms, straight chain or branched chain, hydrophilic or fluorophilic;
- R3 and R4 are independently H, halogen, alkyl, aryl or arylalkyl, alkoxy;
- R3 or R4+R2 can be a saturated or an unsaturated cycloalkane;
- and “” represents a single bond or a double bond provided that at least one of R1, R2, R3 and R4 is halogen.
Dependencies are inferred from the claim text.