Polynucleotide compositions
OwnerAlexander V. Kabanov, Valery Y. Alakov +1inventors
InventorsAlexander V. Kabanov, Valery Y. Alakov, Sergey V. Vinogradov
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Abstract
Compositions for stabilizing polynucleic acids and increasing the ability of polynucleic acids to cross cell membranes and act in the interior of a cell. In one aspect, the invention provides a polynucleotide complex between a polynucleotide and certain polyether block copolymers. The polynucleotide complex can further include a polycationic polymer, as well as suitable targeting molecules and surfactants. The invention also provides a polynucleotide complex between a polynucleotide and a block copolymer comprising a polyether block and a polycation block.
Claims13
A polymer of a plurality of covalently bound polymer segments wherein said segments comprise:
- (a) at least one polycation segment which is a cationic homopolymer or copolymer comprising at least three cationic amino acids, or at least three aminoalkylene monomers, said monomers being selected from the group consisting of:
- (i) at least one tertiary amino monomer of the formula:
- 15
- and the quaternary salts of said tertiary amino monomer, and
- (ii) at least one secondary amino monomer of the formula:
- 16
- and the acid addition and quaternary salts of said secondary amino monomer, in which:
- R1 is hydrogen, alkyl of 2 to 8 carbon atoms, an A monomer, or a B monomer;
- each of R2 and R3, taken independently of the other, is the same or different straight or branched chain alkanediyl group of the formula:
- —(CzH2z)—
- in which z has a value of from 2 to 8;
- R4 is hydrogen satisfying one bond of the depicted geminally bonded carbon atom;
- and
- R5 is hydrogen, alkyl of 2 to 8 carbon atoms, an A monomer, or a B monomer;
- R6 is hydrogen, alkyl of 2 to 8 carbon atoms, an A monomer, or a B monomer;
- R7 is a straight or branched chain alkanediyl group of the formula:
- —(CzH2z)—
- in which z has a value of from 2 to 8;
- and
- R8 is hydrogen, alkyl of 2 to 8 carbon atoms, an A monomer, or a B monomer;
- and
- (b) at least one water-soluble nonionic polymer segment.
A copolymer comprising at least one polynucleotide segment and at least one polyether segment, said polyether segment comprising oxyethylene and oxypropylene.
Dependencies are inferred from the claim text.