Sustained-release preparation for AII antagonist, production and use thereof
AssigneeTakeda Pharmaceutical Company Limited
InventorsYasutaka Igari, Akira Saikawa, Yoshiyuki Inada, Shigeru Kamei
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Abstract
The present invention is to provide a sustained-release preparation which comprises a compound having angiotensin II antagonistic activity, its pro-drug or their salt, and a biodegradable polymer, and if necessary, a polyvalent metal, and which is highly stable and active and shows angiotensin II antagonistic activity with maintaining circadian rhythm of blood pressure for a long time.
Claims24
A sustained-release preparation which comprises a compound having angiotensin II antagonistic activity (excluding 2-ethyl-5,7-dimethyl-3-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazo[4,5-b]pyridine and a salt thereof), its pro-drug or their salt, and a biodegradable polymer.
A sustained-release preparation which comprises a compound having angiotensin II antagonistic activity, its pro-drug or their salt, biodegradable polymer and a polyvalent metal.
Dependencies are inferred from the claim text.