Methods of producing dispersible pharmaceutical compositions
OwnerAndrew G. Franz, Elaine A. Strauss +2inventors
InventorsAndrew G. Franz, Elaine A. Strauss, Phillip A. DiMenna, Rocco L. Gemma
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Abstract
The present invention generally relates to stable pharmaceutical compositions, and methods of making and administering such compositions. In one aspect, the invention features stabilized pharmaceutical compositions that include pharmaceutically active ingredients such as levothyroxine (T4) sodium and liothyronine (T3) sodium (thyroid hormone drugs), preferably in an immediate release solid dosage form. Also provided are methods for making and using such immediate release and stabilized compositions.
Claims11
A method of producing a dispersible pharmaceutical composition comprising
- (a) mixing an active pharmaceutically active ingredient with microcrystalline u-cellulose and a crosscarmellose salt to make a blend, and
- (b) compressing the blend in a ratio of initial volume to final volume of between about 2:1 to about 5:1, to produce the pharmaceutical composition in solid form.
Dependencies are inferred from the claim text.