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OwnerWilliam Woodson Van Osdol, Robert Martin Gale +3inventors
InventorsWilliam Woodson Van Osdol, Robert Martin Gale, David Henry Brandwein, Rama Padmanabhan, Joan Sunram
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Composition of matter for application to a body surface or membrane to administer a N-(2,5-Disubstituted phenyl)-N′-(3-substituted phenyl)-N′-methyl guanidine by permeation through the body surface or membrane, the composition comprising the guanidine compound to be administered, at a therapeutically effective rate, optionally in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices and methods for the transdermal administration of a guanidine for the prevention of neuropathic pain, neuropsychological deficits resulting from cardiac surgery (CABG), and other neurological disorders.
A composition of matter for the transdermal administration of a therapeutic agent comprising a compound selected from the group consisting of N-(2,5-disubstituted phenyl)-N′-(3-substituted phenyl)-N′-methyl guanidines and pharmaceutically acceptable salts thereof, in a carrier effective to permit sustained release of the compound at a therapeutically effective rate during an administration period.
A device for the transdermal administration of a therapeutic agent at a therapeutically effective rate, comprising:
A method for treating an individual in need of guanidine therapy comprising transdermally administering guanidine and simultaneously coadministering a permeation enhancer to the individual wherein a therapeutically effective amount of guanidine is delivered at a therapeutically effective rate during an administration period in order to achieve and maintain therapeutic blood or plasma levels of guanidine throughout a substantial portion of the administration period.
Dependencies are inferred from the claim text.