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US 2003/0198658 A1Published application
Carbon-substituted diketopiperazine delivery systems
AssigneeEmisphere Technologies, Inc.
InventorSamuel J. Milstein
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Abstract
Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and (b) a carrier of at least one mono-C-substituted or di-C-Substituted diketopiperazine. Methods for preparing these compositions and administering these compositions are also provided.
Claims20
A delivery composition comprising:
- (a) an active agent;
- and
- (b) at least one diketopiperazine selected from the group consisting of:
- (i) a mono C-substituted diketopiperazine and
- (ii) a di-C-substituted diketopiperazine.
2 more elements
A pharmacological composition comprising:
- (a) at least one pharmacologically active agent;
- and
- (b) at least one diketopiperazine selected from the group consisting of:
- (i) a mono-C-substituted diketopiperazine and
- (ii) a di C-substituted diketopiperazine.
2 more elements
A method for preparing microspheres containing an active agent, said method comprising:
- (A) solubilizing, in a solvent, at least one diketopiperazine selected from the group consisting of:
- (i) a mono-C-substituted diketopiperazine and
- (ii) a di-N-substituted diketopiperazine. to yield a diketopiperazine solution;
- and
- (B) contacting said diketopiperazine solution with said active agent and a precipitator solution in which said diketopiperazine is insoluble.
2 more elements
Dependencies are inferred from the claim text.