N-acetylamino acids, related N-acetyl compounds and their topical use
OwnerRuey J. Yu, Eugene J. Van Scottinventors
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Abstract
Compositions comprising N-acetylamino acids and/or related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. The N-acetylamino acid and/or related N-acetyl compound composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.
Claims20
A composition comprising (A) a pharmaceutically acceptable vehicle for topical treatment of cosmetic conditions or dermatological disorders and (B) a therapeutically effective amount of at least one compound selected from the group consisting of (1) an N-acetylamino acid selected from the group consisting of N-acetyl pyroglutaminc acid, N-acetyl phenylalaninol, N,S-diacetylarmino acids, and isomeric or nonisomeric, free acid, salt, lactone, amide, or ester forms thereof, and (2) an N-acetyl compound selected from the group consisting of N-acetylpolyamines, N,N′-diacetylpolyamines, N-acetyl-caldine, N-acetyl-spermidine, N-acetyl-homospermidine, N-acetyl-thermine, N-acetyl-spermine, N-acetyl-thermospermine, N-acetyl-homospermine, N-acetyl-caldopentamine, N-acetyl-homocaldopentamine, N-acetyl-caldohexamine, N-acetyl-homocaldohexamine, N-acetyl-tris(3-aminopropyl)amine, N-acetyl-tetrakis(3-aminopropyl)amine, N-acetyl-amantadine, N-acetyl-adenosine, N-acetyl-adenosine-phosphoric acid, N-acetyl-piperazine, and N-acetyl guanine.
A composition comprising:
- (A) a pharmaceutically acceptable vehicle for topical treatment of cosmetic conditions or dermatological disorders,
- (B) a therapeutically effective amount of at least one compound selected from the group consisting of (1) an N-acetylamino acid selected from the group consisting of N-acetyl pyroglutaminc acid, N-acetyl phenylalaninol, N,S-diacetylamino acids, and isomeric or nonisomeric, free acid, salt, lactone, amide, or ester forms thereof, and (2) an N-acetyl compound selected from the group consisting of N-acetylpolyamines, N,N′-diacetylpolyamines, N-acetyl-caldine, N-acetyl-spermidine, N-acetyl-homospermidine, N-acetyl-thermine, N-acetyl-spermine, N-acetyl-thermospermine, N-acetyl-homospermine, N-acetyl-caldopentamine, N-acetyl-homocaldopentamine, N-acetyl-caldohexamine, N-acetyl-homocaldohexamine, N-acetyl-tris(3-aminopropyl)amine, N-acetyl-tetrakis(3-aminopropyl)amine, N-acetyl-amantadine, N-acetyl-adenosine, N-acetyl-adenosine-phosphoric acid, N-acetyl-piperazine, and N-acetyl guanine, and
- (C) a cosmetic, pharmaceutical or other topical agent.
A composition comprising (A) a pharmaceutically acceptable vehicle for topical treatment of cosmetic conditions or dermatological disorders and (B) at least 1% by total weight of the composition of at least one compound selected from the group consisting of (1) an N-acetyamino acid selected from the group consisting of N-acetyl pyroglutaminc acid, N-acetyl phenylalaninol, N,S-diacetylamino acids, and isomeric or nonisomeric, free acid, salt, lactone, amide, or ester forms thereof, and (2) an N-acetyl compound selected from the group consisting of N-acetylpolyamines, N,N′-diacetylpolyamines, N-acetyl-caldine, N-acetyl-spernidine, N-acetyl-homospermidine, N-acetyl-thermine, N-acetyl-spermine, N-acetyl-thermospermine, N-acetyl-homospermine, N-acetyl-caldopentamine, N-acetyl-homocaldopentamine, N-acetyl-caldohexamine, N-acetyl-homocaldohexamine, N-acetyl-tris(3-aminopropyl)amine, N-acetyl-tetrakis(3-aminopropyl)amine, N-acetyl-amantadine, N-acetyl-adenosine, N-acetyl-adenosine-phosphoric acid, N-acetyl-piperazine, and N-acetyl guanine.
A composition comprising:
- (A) a pharmaceutically acceptable vehicle for topical treatment of cosmetic conditions or dermatological disorders,
- (B) at least 1% by total weight of the composition of at least one compound selected from the group consisting of (1) an N-acetylamino acid selected from the group consisting of N-acetyl pyroglutaminc acid, N-acetyl phenylalaninol, N,S-diacetylamino acids, and isomeric or nonisomeric, free acid, salt, lactone, amide, or ester forms thereof, and (2) an N-acetyl compound selected from the group consisting of N-acetylpolyamines, N,N′-diacetylpolyamines, N-acetyl-caldine, N-acetyl-spermidine, N-acetyl-homospermidine, N-acetyl-thermine, N-acetyl-spermine, N-acetyl-thermospermine, N-acetyl-homospermine, N-acetyl-caldopentamine, N-acetyl-homocaldopentamine, N-acetyl-caldohexamine, N-acetyl-homocaldohexamine, N-acetyl-tris(3-aminopropyl)amine, N-acetyl-tetrakis(3-aminopropyl)amine, N-acetyl-amantadine, N-acetyl-adenosine, N-acetyl-adenosine-phosphoric acid, N-acetyl-piperazine, and N-acetyl guanine, and
- (C) a cosmetic, pharmaceutical or other topical agent.
A method for treating cosmetic conditions and dermatological disorders comprising topically applying a composition comprising (A) a pharmaceutically acceptable vehicle for topical treatment of cosmetic conditions or dermatological disorders and (B) a therapeutically effective amount of a composition comprising at least one compound selected from the group consisting of (1) an N-acetylamino acid selected from the group consisting of N-acetyl pyroglutaminc acid, N-acetyl phenylalaninol, N,S-diacetylamino acids, and isomeric or nonisomeric, free acid, salt, lactone, amide, or ester forms thereof, and (2) an N-acetyl compound selected from the group consisting of N-acetylpolyamines, N,N′-diacetylpolyamines, N-acetyl-caldine, N-acetyl-spermidine, N-acetyl-homospermidine, N-acetyl-thermine, N-acetyl-spermine, N-acetyl-thermospermine, N-acetyl-homospermine, N-acetyl-caldopentamine, N-acetyl-homocaldopentamine, N-acetyl-caldohexamine, N-acetyl-homocaldohexamine, N-acetyl-tris(3-aminopropyl)amine, N-acetyl-tetrakis(3-aminopropyl)amine, N-acetyl-amantadine, N-acetyl-adenosine, N-acetyl-adenosine-phosphoric acid, N-acetyl-piperazine, and N-acetyl guanine.
A method for treating cosmetic conditions and dermatological disorders comprising topically applying a composition comprising:
- (A) a pharmaceutically acceptable vehicle for topical treatment of cosmetic conditions or dermatological disorders,
- (B) a therapeutically effective amount of at least one compound selected from the group consisting of (1) an N-acetylamino acid selected from the group consisting of N-acetyl pyroglutaminc acid, N-acetyl phenylalaninol, N,S-diacetylamino acids, and isomeric or nonisomeric, free acid, salt, lactone, amide, or ester forms thereof, and (2) an N-acetyl compound selected from the group consisting of N-acetylpolyamines, N,N′-diacetylpolyamines, N-acetyl-caldine, N-acetyl-spermidine, N-acetyl-homospermidine, N-acetyl-thermine, N-acetyl-spermine, N-acetyl-thermospermine, N-acetyl-homospermine, N-acetyl-caldopentamine, N-acetyl-homocaldopentamine, N-acetyl-caldohexamine, N-acetyl-homocaldohexamine, N-acetyl-tris(3-aminopropyl)amine, N-acetyl-tetrakis(3-aminopropyl)amine, N-acetyl-amantadine, N-acetyl-adenosine, N-acetyl-adenosine-phosphoric acid, N-acetyl-piperazine, and N-acetyl guanine, and
- (C) a cosmetic, pharmaceutical or other topical agent.
Dependencies are inferred from the claim text.