gM-negative EHV-mutants
AssigneeBoehringer Ingelheim Vetmedica GmbH
InventorsKnut Elbers, Nikolaus Osterrieder, Christian Seyboldt
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Abstract
This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of the invention relate to nucleic acids coding said viruses, pharmaceutical compositions comprising these viruses or nucleic acids and uses thereof. The invention also relates to methods for improving the immune response induced by an EHV vaccine against wild type EHV infections, methods for the prophylaxis and treatment of EHV infections and methods for distinguishing wild type EHV infected animals from animals treated with EHV's according to the invention.
Claims15
An Equine Herpes Virus wherein a protein gM is essentially absent.
An Equine Herpes Virus wherein a protein gM is modified and non-functional.
An Equine Herpes Virus strain HgM-3b1 deposited under accession No. 99101536 with the EACC.
A kit comprising in one or more containers isolated wild type protein gM or modified derivatives thereof and antibodies that specifically bind the wild type protein gM or the modified derivatives thereof.
Dependencies are inferred from the claim text.