Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes
AssigneeBio Merieux
InventorsHerve Perron, Frederic Beseme, Frederic Bedin, Glaucia Paranhos-Baccala, Florence Komurian-Pradel, Colette Jolivet-Reynaud, Bernard Mandrand, Jeremy Alexander Garson, Philip William Tuke
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Abstract
The invention provides viral material and nucleotide fragments associated with multiple sclerosis and/or rheumatoid arthritis for use in methods of diagnosis, prophylaxis, and therapy.
Claims14
An isolated nucleic acid comprising the pol gene of a retrovirus associated with multiple sclerosis or rheumatoid arthritis.
A nucleotide fragment comprising:
- (i) a coding nucleotide sequence selected from the group consisting of SEQ ID NO:
- 87, its complementary sequence, SEQ ID NO:
- 88, its complementary sequence, and sequences encoding the peptide sequence defined by SEQ ID NO:
- 89, or
- (ii) a portion of said coding nucleotide sequence, which encodes a peptide that is recognized by sera of patients infected with the MSRV-1 virus.
An isolated or purified polypeptide selected from the group consisting of a polypeptide comprising peptide sequence SEQ ID NO:
- 90, a polypeptide consisting of peptide sequence SEQ ID NO:
- 90, a polypeptide encoded by an open reading frame beginning at nucleotide 18 and ending at nucleotide 340 of SEQ ID NO:
- 87, and an equivalent polypeptide thereof which exhibits the proteolytic activity of a polypeptide of SEQ ID NO:
- 90.
An isolated or purified polypeptide selected from the group consisting of a polypeptide comprising peptide sequence SEQ ID NO:
- 91, a polypeptide consisting of peptide sequence SEQ ID NO:
- 91, a polypeptide encoded by an open reading frame beginning at nucleotide 341 and ending at nucleotide 2304 of SEQ ID NO:
- 87, and an equivalent polypeptide thereof which exhibits the reverse transcriptase activity of a polypeptide of SEQ ID NO:
- 91.
An isolated or purified polypeptide selected from the group consisting of a polypeptide comprising peptide sequence SEQ ID NO:
- 92, a polypeptide consisting of peptide sequence SEQ ID NO:
- 92, a polypeptide encoded by an open reading frame beginning at nucleotide 1858 and ending at nucleotide 2304 of SEQ ID NO:
- 87, and an equivalent polypeptide which exhibits the ribonuclease activity of a polypeptide of SEQ ID NO:
- 92.
Polypeptide of SEQ ID NO:
- 89.
Dependencies are inferred from the claim text.