Methods and compositions for treating inflammatory bowel diseases relating to human tumor necrosis factor-gamma-beta
AssigneeHuman Genome Sciences, Inc.
InventorsGuo-Liang Yu, Jian Ni, Craig A. Rosen, Jun Zhang, Ping Wei
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Abstract
The present invention encompasses methods for detection, diagnosis, prevention, treatment, and/or amelioration of inflammatory bowel diseases and disorders using TNF-gamma-β and its receptors DR3 and TR6. In particular the invention encompasses methods of using TNF-gamma-β, DR3 and TR6 polypeptides, as well as antibodies, and antagonists thereto, in the diagnosis, prognosis and treatment of ulcerative colitis and/or Crohn's disease. Methods of screening for antagonists of the TNF-gamma-β polypeptide, together with therapeutic uses of such antagonists are also disclosed.
Claims27
A method for treating or ameliorating a disease or disorder of the gastrointestinal tract comprising administering a composition comprising an antagonist of TNF-gamma-β to a person with, or suspected of having, said disease or disorder.
A method of diagnosing a disease or disorder of the gastrointestinal tract comprising detecting abnormal levels of a polypeptide selected from the group consisting of:
- (a) a TNF-gamma-β polypeptide consisting of amino acid residues 62-251 of SEQ ID NO:2;
- (b) a polypeptide consisting of amino acid residues 25-201 of SEQ ID NO:4 or a fragment thereof;
- and
- (c) a polypeptide comprising amino acid residues 31-300 of SEQ ID NO:6 or a fragment thereof, in a biological sample.
Dependencies are inferred from the claim text.