Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
AssigneeThe UAB Research Foundation
InventorsTong Zhou, Robert P. Kimberly, William J. Koopman, Albert F. LoBuglio, Donald J. Buchsbaum
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Abstract
An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of DR5 and DR4 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
Claims104
A purified antibody which specifically binds a TRAIL receptor DR4, wherein said antibody, in its soluble form, has in vivo and in vitro apoptosis-inducing activity in target cells expressing DR4.
A monoclonal antibody having the same epitope specificity as hybridoma 2E12 having ATCC Accession Number PTA-3798.
A monoclonal antibody produced by hybridoma 2E12 having ATCC Accession Number PTA-3798.
An isolated nucleic acid, comprising a nucleotide sequence that encodes a heavy chain immunoglobulin of an antibody capable of binding TRAIL receptor DR4 and capable of inducing apoptosis of a cell with DR4 receptors.
An isolated nucleic acid, comprising a nucleotide sequence that encodes a light chain immunoglobulin of an antibody capable of binding TRAIL receptor DR4 and capable of inducing apoptosis of a cell with DR4 receptors.
A purified polypeptide comprising an amino acid sequence of a heavy chain immunoglobulin of an antibody capable of binding TRAIL receptor DR4 and capable of inducing apoptosis of a cell with DR4 receptors.
A purified polypeptide comprising an amino acid sequence of a light chain immunoglobulin of an antibody capable of binding TRAIL receptor DR4 and capable of inducing apoptosis of a cell with DR4 receptors.
Dependencies are inferred from the claim text.