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OwnerShyam S. Mohapatra, Mukesh Kumar +1inventors
InventorsShyam S. Mohapatra, Mukesh Kumar, Aruna Behera
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The subject invention concerns an effective therapy for asthma, including allergic disease, using cytokine gene expression therapy. The subject invention further pertains to the use of adenovirus-medicated IFN-γ(Ad-IFN-γ)gene transfer to prevent or treat allergic disease and asthma, including associated conditions such as allergen-induced airway inflammation and airway hyperresponsiveness. The subject invention includes a method for effectively attenuating allergen-induced airway inflammation and airway hyperresponsiveness by administering to the respiratory tract Ad-IFN-γ, to affect IL-12 and Stat-4 levels. The subject invention also provides compositions for gene therapy for asthma by the transfer of IFN-γ.
A method of enhancing IFN-γ expression to regulate the production of cytokines secreted by Th2 cells comprising administering an adenovirus comprising an IFN-γ gene in a mammal.
A method if enhancing IFN-γ expression to regulate the production of cytokines secreted by Th2 cells comprising administering an adeno-associated virus comprising an IFN-γ gene in a mammal.
A pharmaceutical composition comprising an adenovirus comprising an IFN-γ gene.
A pharmaceutical composition comprising an adeno-associated virus comprising an IFN-γ gene.
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