T1 receptor-like ligand II and uses thereof
AssigneeHuman Genome Sciences, Inc.
InventorsJian Ni, Reiner L. Gentz, Steven M. Ruben
Life of this patent
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Abstract
The present invention relates to a novel T1 Receptor (T1R)-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same. This invention further relates to pharmaceutical compositions and formulations comprising T1R-like ligand II. Also provided are methods of using T1R-like ligand II polynucleotides, polypeptides, antibodies or agonists/antagonists for therapeutic and diagnostic purposes. Diagnostic kits are further provided.
Claims11
A method of stimulating the proliferation and/or differentiation of cells of hematopoietic origin, comprising contacting said cells with the T1R-like ligand II or agonist thereof.
A method of inhibiting the proliferation and/or differentiation of cells of hematopoietic origin, comprising contacting said cells with the T1R-like ligand II or antagonist thereof.
A method useful during the diagnosis of a disorder, comprising:
- (a) measuring the T1R-like ligand II gene expression level in cells or body fluid of an individual;
- and
- (b) comparing the T1R-like ligand II gene expression level of said individual with a standard T1R-like ligand IT gene expression level, whereby an increase or decrease in the T1R-like ligand II gene expression level over said standard is indicative of a T1R-like ligand II-related disorder.
Dependencies are inferred from the claim text.