Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
OwnerLawrence Green, Nicolay V. Sinackevichinventors
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Abstract
The present invention provides compositions and methods for treatment of a variety of disease states. The methods generally comprise administering to a host a therapeutically effective amount of a dipeptide having the formula X-Tryptophan or a pharmaceutically acceptable salt thereof, wherein x is glutamine, glutamate, leucine, or isoleucine. The present invention is useful for treatment of infections hyperimmune states, immunodeficiencies, and the like.
Claims17
Use of a dipeptide having the formula X-Tryptophan or a pharmaceutically acceptable salt thereof, wherein X is glutamine, leucine or isoleucine in the manufacture of a medicament for any of the following:
- (a) treatment of infection with a mycobacterial or other bacterial organism, a fungus or a virus;
- (b) infection by a parasite;
- (c) prevention of rejection of a graft.
- (d) augmenting a vaccination response
Use according to claim 3, wherein the medicament is for treatment of Mycobacterium tuberculosis and further comprises an anti-infective agent selected from isoniazid, rifampin, streptomycin, and at least one of the antibiotics of the pyrazinamide group.
Use according to any preceding claim, wherein the infection is by a parasite which is of a leishmania species or a plasmodium species.
Use according to any preceding claim, wherein the medicament which is manufactured provides a dose of about 1 to 10 μg/kg of the hosts' body weight.
Use according to any preceding claim, wherein the medicament is for treatment of humans, avians, bovines, equines, procines or fish.
Use according to any preceding claim, wherein the medicament is for treatment of the kidney, bone, lung, skin, stomach, small intestine or colon.
Use according to any preceding claim, wherein the medicament is for the treatment of Dengue virus, influenza virus, a hepatitis virus, or a herpesvirus.
Use according to any preceding claim, wherein X is leucine or isoleucine.
A pharmaceutical composition comprising a therapeutically effective amount of a dipeptide having the formula X-Tryptophan or a pharmaceutically acceptable salt thereof, wherein X is leucine or isoleucine;
- and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.