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OwnerRobert M. Platz, John S. Patton +2inventors
InventorsRobert M. Platz, John S. Patton, Linda Foster, Mohammed Eljamal
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According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture content of less than about 10% by weight (%w) water, usually below about 5%w and preferably less than about 3%w; a particle size of about 1.0-5.0 (m mass median diameter (MMD), usually 1.0-4.0 (m MMD, and preferably 1.0-3.0 (m MMD; a delivered dose of about (30%, usually (40%, preferably (50%, and most preferred (60%; and an aerosol particle size distribution of about 1.0-5.0 (m mass median aerodynamic diameter (MMAD), usually 1.5-4.5 (m MMAD, and preferably 1.5-4.0 MMAD. Such composition are of pharmaceutical grade purity.
A dispersible pharmaceutical-based dry powder composition for pulmonary delivery, said composition comprising a therapeutically effective amount of the pharmaceutical in combination with a pharmaceutically acceptable carrier.
A unit dosage form for pulmonary delivery of a pharmaceutical, which dosage form comprises a unit dosage receptacle containing a dispersible pharmaceutical-based dry powder composition, which composition comprises a therapeutically effective amount of the pharmaceutical in combination with a pharmaceutically acceptable carrier.
A method of treating a disease state responsive to treatment by a pharmaceutical, which method comprises pulmonarily administering to a subject in need thereof a physiologically effective amount of a dispersible pharmaceutical-based dry powder composition that comprises a therapeutically effective amount of the macromolecule in combination with a pharmaceutically acceptable carrier.
A method for aerosolizing a pharmaceutical-based dry powder composition that comprises a therapeutically effective amount of the pharmaceutical in combination with a pharmaceutically acceptable carrier, which method comprises:
A method for preparing a spray-dried, pharmaceutical-based dry powder composition that comprises a therapeutically effective amount of the macromolecule and a pharmaceutically acceptable carrier, which method comprises spray-drying an aqueous mixture of the macromolecule and the carrier under conditions to provide a respirable dry powder.
A spray-dried, macromolecule-based dry powder composition for pulmonary delivery, said composition comprising a therapeutically effective amount of the macromolecule in combination with a pharmaceutically acceptable carrier that comprises HSA and a carbohydrate bulking agent, wherein the composition is substantially free from penetration enhancers and about 95% of the mass of the dry powder composition has a particle size of less than 10 μm.
Dependencies are inferred from the claim text.