Novel imaging probes
AssigneeCarboMer, Inc.
InventorManssur Yalpani
Life of this patent
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Abstract
The present invention relates to fluorinated and paramagnetic polyuronides (Formulas I-IV) and proteins useful as imaging probes, diagnostic agents and contrast agents. Additionally, the present invention relates to imaging methods employing the present compounds of Formulas I-IV.
Claims17
A fluorinated or paramagnetic polyuronide polymer comprising a polymer of Formula I, II , III or IV
- 19
- and pharmaceutically acceptable salts thereof for the polymers that are capable of forming salts, wherein
- for Formula I:
- R1 represents OH, OX, X;
- R2 represents OH, OX, X;
- R3 represents OH, OY, OX, NHX, alkyl, alkoxyalkyl;
- R4 represents C═O, CH2, CNX, CF2;
- for Formula II:
- R1 represents OH, OX, X, OR4;
- R2 represents OH, OX, X, OR4;
- R3 represents OH, Y, X;
- R4=acyl, alkly or aryl
- for Formula III:
- R1 represents OH, OX, X;
- R2 represents OH, OX, X;
- R3 represents H, N(X)3;
- for Formula IV:
- R1 represents OH, OX, X;
- R2 represents OH, OX, X, —OA(X)O— or OA(R5)O—;
- R5 represents alkyl or acyl and A represents a non-paramagnetic ion
- wherein M is any paramagnetic ion of the transition metal or lanthanide series, and “a” is a whole number and “b” is 1/a;
- wherein for all of the formulas I-IV
- X represents a fluorine containing moiety, a luminescent residue, a fluorescent residue, a fluorinated luminescent residue or a fluorinated fluorescent residue;
- Y represents CH2C(OH)CH3;
- m, p, x, y, z represents 0-150;
- and
- n is from 10-10,000 inclusive.
A paramagnetic alginate bead comprising paramagnetic gadolinium alginate beads or paramagnetic iron oxide alginate beads.
A paramagnetic particle comprising a paramagnetic iron oxide alginate-coated particle, a paramagnetic Iron oxide alginate-coated particle or a paramagnetic iron oxide dextran-coated particle.
A bioactive protein paramagnetic conjugate comprising a bioactive protein conjugated or complexed with a paramagnetic ion of the transition metal or lanthanide series.
Dependencies are inferred from the claim text.