Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation

A solution for use in the inhibition of tumor cell attachment and implantation during a surgical procedure within a body cavity of a patient in need of such treatment, comprising:

• therapeutically effective amounts of at least one tumor-cell anti-adhesion agent and at least one pain/inflammation inhibitory agent in a dilute solution within a liquid irrigation carrier, the agents being selected to act on differing molecular targets, the at least one tumor-cell anti-adhesion agent being selected to be deliverable by irrigation in the body cavity to provide without metabolic transformation a therapeutic anti-tumor cell attachment and anti-tumor cell implantation effect.

A solution for use in inhibiting tumor cell adhesion, pain and inflammation at a wound during a surgical procedure, comprising:

• therapeutically effective amounts of at least one tumor-cell anti-adhesion agent and at least one pain/inflammation inhibitory agent in a dilute solution within a liquid irrigation carrier, the agents being selected to act on differing molecular targets, the at least one tumor-cell anti-adhesion agent being selected from the group consisting of CD44 receptor antagonists, integrin receptor antagonists, selectin receptor antagonists and inhibitors of matrix metalloproteinases and being selected to be deliverable by irrigation of the wound to provide without metabolic transformation a therapeutic anti-adhesion effect.

A solution for use in inhibiting tumor cell adhesion, pain and inflammation at a wound during a surgical procedure, comprising:

• therapeutically effective amounts of at least one tumor-cell anti-adhesion agent and at least one pain/inflammation inhibitory agent in a dilute solution within a liquid carrier, the agents being selected to act on a plurality of differing molecular targets, the at least one tumor-cell anti-adhesion agent being selected from the group consisting of CD44 receptor antagonists, integrin receptor antagonists and selectin receptor antagonists, and being selected to be deliverable to the wound to provide without metabolic transformation a therapeutic anti-adhesion effect.

A solution for use in inhibiting tumor cell adhesion at a wound during a surgical procedure, comprising:

• therapeutically effective amounts of a first tumor-cell anti-adhesion agent and a second tumor-cell anti-adhesion agent in a dilute solution within a liquid irrigation carrier, the agents being selected to act on differing molecular targets, at least one of the agents being selected to be deliverable by irrigation of the wound to provide without metabolic transformation a therapeutic anti-adhesion effect.

A solution for use in inhibiting tumor cell adhesion, pain and inflammation at a wound during a surgical procedure, comprising:

• therapeutically effective amounts of at least one tumor-cell anti-adhesion agent and at least one pain/inflammation inhibitory agent in a dilute solution within a sustained release carrier, the agents being selected to act on differing molecular targets, the at least one tumor-cell anti-adhesion agent being selected to provide without metabolic transformation a therapeutic anti-adhesion effect at the wound.

A solution for use in inhibiting tumor cell adhesion at a wound during a surgical procedure, comprising:

• therapeutically effective amounts of a first tumor-cell anti-adhesion agent and a second tumor-cell anti-adhesion agent in a dilute solution within a sustained release carrier, the agents being selected to act on differing molecular targets, at least one of the agents being selected to provide without metabolic transformation a therapeutic anti-adhesion effect.

A solution for use in inhibition of tumor cell attachment and implantation during a surgical procedure within a body cavity of a patient in need of such treatment, comprising:

• therapeutically effective amounts of at least one tumor-cell anti-adhesion agent and at least one pain/inflammation inhibitory agent in a dilute solution within a sustained release carrier, the agents being selected to act on differing molecular targets, the at least one tumor-cell anti-adhesion agent being selected to provide in the body cavity without metabolic transformation a therapeutic anti-tumor cell attachment and anti-tumor cell implantation effect.

A solution for use in inhibition of tumor cell attachment and implantation during a surgical procedure within a body cavity of a patient in need of such treatment, comprising:

• therapeutically effective amounts of a first tumor-cell anti-adhesion agent and a second tumor-cell anti-adhesion agent in a dilute solution within a sustained release carrier, the agents being selected to act on differing molecular targets, at least one of the agents being selected to provide in the body cavity without metabolic transformation a therapeutic anti-tumor cell attachment and anti-tumor cell implantation effect.