Generation of spatially-averaged excitation-emission map in heterogeneous tissue
OwnerWei Dong Tian, Pierre Trepagnierinventors
Life of this patent
Estimating the term…
Abstract
An instrument for evaluating fluorescence of a heterogeneous tissue includes means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths, means for collecting emission radiation from the two-dimensional portion of the tissue surface simultaneously with excitation of the portion, and means for forming a two-dimensional excitation-emission map of the excitation radiation and the simultaneously collected emission radiation and spatially averaging the excitation and emission radiation.
Claims4
A method for evaluating fluorescence of a heterogeneous tissue comprising:
- exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths;
- collecting emission radiation from said two-dimensional portion of the tissue surface simultaneously with excitation of said portion;
- and
- forming a two-dimensional excitation-emission map of said excitation radiation and said simultaneously collected emission radiation and spatially averaging said excitation and emission radiation.
An instrument for evaluating fluorescence of a heterogeneous tissue comprising:
- means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths;
- means for collecting emission radiation from said two-dimensional portion of the tissue surface simultaneously with excitation of said portion;
- and
- means for forming a two-dimensional excitation-emission map of said excitation radiation and said simultaneously collected emission radiation and spatially averaging said excitation and emission radiation.
A method of rapidly gathering UV and visible fluorescence spectra in vivo spatially averaged over tissue, said method comprising the steps of:
- illuminating strips of tissue with excitation radiation simultaneously at a plurality of excitation wavelengths;
- collecting emission radiation simultaneously from said strips of tissue with the step of illuminating with said plurality of excitation wavelengths;
- and
- disposing said emission radiation onto a two-dimensional array of detector elements, wherein said two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map, in which all elements in said map are collected at once.
An instrument for rapidly gathering UV and visible fluorescence spectra in vivo spatially averaged over tissue, comprising:
- means for illuminating strips of tissue with excitation radiation simultaneously at a plurality of excitation wavelengths;
- means for collecting collecting emission radiation simultaneously from said strips of tissue with the step of illuminating with said plurality of excitation wavelengths;
- and
- means for disposing said emission radiation onto a two-dimensional array of detector elements, wherein said two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map, in which all elements in said map are collected at once.
Dependencies are inferred from the claim text.