Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors

A detection system for detecting radiation emitted from an internally administered therapeutic radiolabeled analyte, comprising:

• at least one wireless implanted radiation sensor configured for in vivo operation, the at least one sensor being configured to directly and/or indirectly detect beta radiation from an internally administered beta radioactive source proximate to a targeted cancer treatment site in the body, wherein the at least one sensor is configured to detect internally emitted beta radiation, at least intermittently, over a period of desired time;
• and
• an external reader operably associated with the at least one radiation sensor and configured to receive signal data associated with the direct and/or indirectly detected radiation from the at least one sensor, wherein said system includes computer program code for dynamically monitoring selected in vivo parameters associated with one or more of the dose, uptake and/or processing of the radiation from the internally administered radioactive source at the targeted cancer treatment site.

A computer program product for evaluating radiation dose received at a target treatment site from a radiolabeled analyte administered in response to a cancer treatment regimen, said computer program product comprising:

• computer readable program code for receiving a plurality of measurements of radiation detected in vivo in tissue from a chronically implanted sensor located about a local targeted cancer treatment site in the body of a human subject undergoing treatment for cancer, the detected radiation corresponding to radiation emitted from a selected beta radiolabeled analyte and/or radiation source administered internally to the subject;
• and
• computer readable program code for computing a patient specific in vivo radiation dose received at a cancer treatment site in a human subject based on the plurality of received measurements.