Cerebral perfusion augmentation
AssigneeCoAxia, Inc.
InventorDenise R. Barbut
Life of this patent
Estimating the term…
Abstract
Methods are provided for partial aortic occlusion for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. A catheter is advanced into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region. The expandable member is located downstream from the takeoff of a carotid artery. The expandable member is expanded to at least partially obstruct blood flow in the aorta. A physiologic parameter is measured that indicates adequacy of cerebral perfusion. The expansion of the expandable member is adjusted based on the measured physiologic parameter. Other medical devices, such as an atherectomy catheter, can be inserted distal the occluder to provide therapeutic intervention.
Claims55
A method for increasing cerebral blood flow, comprising the steps of:
- advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region;
- locating the expandable member downstream from the takeoff of a carotid artery;
- expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole;
- measuring a physiologic parameter that indicates adequacy of cerebral perfusion;
- and
- adjusting the expansion of the expandable member based on the measured physiologic parameter.
A method for increasing cerebral blood flow, comprising the steps of:
- advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region;
- locating the expandable member downstream from the takeoff of a carotid artery;
- expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole;
- measuring a physiologic parameter;
- and
- adjusting the expansion of the expandable member if the measured physiologic parameter falls outside of a predetermined range.
A method for increasing cerebral blood flow, comprising the steps of:
- advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region;
- locating the expandable member downstream from the takeoff of a carotid artery;
- expanding the expandable member to at least partially obstruct blood flow in the aorta;
- measuring a physiologic parameter that indicates adequacy of cerebral perfusion;
- and
- adjusting the expansion of the expandable member based on the measured physiologic parameter.
A method for increasing cerebral blood flow, comprising the steps of:
- advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and a balloon mounted on the distal region;
- locating the balloon downstream from the takeoff of a carotid artery;
- expanding the balloon by inflating with liquid to at least partially obstruct blood flow in the aorta;
- measuring a physiologic parameter;
- and
- adjusting the expansion of the expandable member based on the measured physiologic parameter.
A method for increasing cerebral blood flow, comprising the steps of:
- providing a catheter having a proximal end, a distal end, and an expandable member mounted on the distal end, and a lumen extending from the proximal end and communicating with a port distal the expandable member;
- advancing the distal end of the catheter into the descending aorta;
- locating the expandable member downstream from the takeoff of a carotid artery;
- and
- expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole, wherein blood pressure or wave form in the proximal aorta is altered.
A method for increasing cerebral blood flow, comprising the steps of:
- providing a catheter having a proximal end, a distal end, and an expandable member mounted on the distal end, and a lumen extending from the proximal end and communicating with a port distal the expandable member;
- advancing the distal end of the catheter into the descending aorta;
- locating the expandable member downstream from the takeoff of a carotid artery;
- and
- expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole, wherein blood pressure in the proximal aorta is altered.
A method for increasing cerebral blood flow, comprising the steps of:
- providing a catheter having a proximal end, a distal end, and an expandable member mounted on the distal end;
- inserting the distal end of the catheter into the descending aorta;
- locating the expandable member downstream from the takeoff of a carotid artery;
- and
- expanding the expandable member to at least partially obstruct blood flow in the aorta and maintaining the expanded expandable member during systole, and wherein blood flow to the cerebral vasculature increases and alters the pulse wave.
A method for increasing cerebral blood flow, comprising the steps of:
- providing a catheter having a proximal end, a distal end, and an expandable member mounted on the distal end;
- advancing the distal end of the catheter into the descending aorta;
- locating the expandable member downstream from the takeoff of a carotid artery;
- expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole;
- measuring a first blood pressure at a location proximal the expandable member and measuring a second blood pressure at a location distal the expandable member;
- and
- adjusting the expandable member based on a comparison of the first and second measured blood pressures.
A method for increasing cerebral blood flow, comprising the steps of:
- providing a catheter having a proximal end, a distal end, and an expandable member mounted on the distal end;
- advancing the distal end of the catheter into the descending aorta;
- locating the expandable member downstream from the takeoff of a carotid artery;
- expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole;
- measuring a first blood pressure at one of a location proximal or distal the expandable member;
- and
- adjusting the expandable member based on a comparison of the first and second measured blood pressures.
A method for increasing cerebral blood flow, comprising the steps of:
- providing a catheter having a proximal end, a distal end, and an expandable member mounted on the distal end;
- advancing the distal end of the catheter into the descending aorta;
- locating the expandable member downstream from the takeoff of a carotid artery;
- expanding the expandable member to at least partially obstruct blood flow in the aorta during systole and diastole;
- measuring a physiologic parameter;
- and
- adjusting the expansion of the expandable member if the measured physiologic parameter falls outside of a predetermined range.
Dependencies are inferred from the claim text.