Process for production of gabapentin intermediate
AssigneeTeva Pharmaceutical Industries Ltd.
InventorStefania Maria Paola Montanari
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Abstract
The invention relates to a novel process for producing a the intermediary compound α,α′,dicyano-β,β-pentamethyleneglutarimide. The process includes the steps of reacting a ketone such as cyclohexanone with ethylcyanoacetate in the presence of ammonium hydroxide.
Claims22
A process for producing a compound of formula I
- 4
- comprising reacting a ketone with ethylcyanoacetate in the presence of ammonium hydroxide.
A process for producing a compound of formula I comprising reacting cyclohexanone and ethylcyanoacetate in the presence of ammonium hydroxide.
A process for producing α,α′,dicyano-β,β-pentamethyleneglutarimide comprising reacting cyclohexanone and ethylcyanoacetate in the presence of ammonium hydroxide.
A method of forming pentamethylene glutaramides by carrying out the Guareschi reaction in the presence of water.
A method of forming pentamethylene glutaramides by carrying out the Guareschi reaction in the presence of ammonium hydroxide.
A method of forming glutaramides by carrying out the Guareschi reaction in the presence of water.
A method of forming glutaramides by carrying out the Guareschi reaction in the presence of ammonium hydroxide.
Dependencies are inferred from the claim text.