4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines

A 4-aryl-1-(indanmethyl or dihydrobenzothiophenemethyl)-piperazine compound of Formula I

• 12
• wherein one of X and Y is CH2 and the other is selected from the group consisting Of CH2 and S;
• Z is N;
• Ar is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2-furanyl, 3-furanyl, 2-pyrimidyl, 1-indolyl, 2-indolyl, 3-indolyl, 1-indol-2-onyl, 3-indol-2-onyl, 3-benzofuranyl,3 2-benzothiophenyl, 3-benzothiophenyl, 1-naphthyl, and 2-naphthyl, wherein each Ar group can be optionally substituted with halogen, lower alkyl, lower alkoxy, lower alkylthio, hydroxy, lower alkylsulfonyl, cyano, trifluoromethyl, trifluromethylsulfonyloxy, cycloalkyl, cycloalkyl-lower-alkyl, nitro, amino, lower alkylamino, di-lower alkylamino, acylamino wherein said acyl moiety is selected from the group consisting of formyl, lower alkyl carbonyl, cycloalkyl carbonyl, and cycloalkyl-lower alkyl or C1-2 alkylenedioxy;
• R1 is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cycloalk(en) yl, cycloalk(en)yl-lower alk(en/yn)yl, phenyl, phenyl-lower alkyl, acyl selected from the group consisting of formyl, lower alkyl carbonyl, cycloalkyl carbonyl, and cycloalkyl-lower alkyl carbonyl, thioacyl wherein said acyl moiety is selected from the group consisting of formyl, lower alkyl carbonyl, cycloalkyl carbonyl, and cycloalkyl-lower alkyl, lower alkylsulfonyl, trifluoromethilsulfonyl, and phenylsulfonyl;
• or
• R1 is a group R9VCO— where V it O or S and R9 is lower alkyl, cycloalkyl, cycloalkyl-lower-alkyl or phenyl, or
• R1 is a group R10R11NCO— or R10R11NCS— wherein R10 and R11 are independently selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, cycloalkyl-lower-alkyl and phenyl, or R10 and R11 taken together with the N-alom to which they are linked, form a pyrrolidinyl, piperidinyl or perhydroazepin group;
• R2 is hydrogen, lower alkyl, cycloalkyl or cycloalkyl-lower-alkyl;
• or R1 and R2 taken together with the N-atom to which they are linked form a group,
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• wherein Q is C═O, C═S or CH2;
• T is NH, S, O or CH2;
• and m is 1-4, inclusive;
• R3-R4 are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkylcarbonyl, phenylcarbonyl, halogen substituted phenylcarbonyl, lower alkoxy, lower alkylthio, hydroxy, lower alkylsulfonyl, cyano, trifluoromethyl, cycloalkyl, cycloalkyl-lower-alkyl and nitro;
• R6 and R7 are each hydrogen or lower alkyl or they can be linked together to form a 3-7 membered carbocyclic ring;
• R8 is hydrogen or lower alkyl;
• wherein any alkyl, cycloalkyl or cycloalkylalkyl group present can be optionally substituted with one or two hydroxy groups, which can be optionally esterified with an aliphatic or aromatic carboxylic acid;
• and any aryl substituent present can be optionally substituted with halogen, lower alkyl, lower alkoxy, lower alkylthio, hydroxy, lower alkylsulfonyl, cyano, trifluoromethyl. trifluoromethylsulfonyloxy, cycloalkyl, cycloalkyl-lower-alkyl or nitro;
• or a pharmaceutically acceptable acid addition salt thereof.