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US 2003/0195338 A1Published application
Concatameric immunoadhesion
AssigneeMedexgen Co., Ltd.
InventorsYong-Hoon Chung, Ji-Woong Han, Hye-Ja Lee, Eun-Yong Choi, Jin-Mi Kim
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AssigneeMedexgen Co., Ltd.
InventorsYong-Hoon Chung, Ji-Woong Han, Hye-Ja Lee, Eun-Yong Choi, Jin-Mi Kim
Estimating the term…
Disclosed are concatameric proteins comprising two soluble domains, in which the C-terminus of a soluble domain of a biologically active protein is linked to the N-terminus of an identical soluble domain or a distinct soluble domain of a biologically active protein. Also, the present invention discloses dimeric proteins formed by formation of intermolecular disulfide bonds at the hinge region of two monomeric proteins formed by linkage of a concatamer of two identical soluble extracellular regions of proteins involving immune response to an Fc fragment of an immunoglobulin molecule, their glycosylated proteins, DNA constructs encoding the monomeric proteins, recombinant expression plasmids containing the DNA construct, host cells transformed or transfected with the recombinant expression plasmids, and a method of preparing the dimeric proteins by culturing the host cells. Further, the present invention discloses pharmaceutical or diagnostic compositions comprising the dimeric protein or its glycosylated form.
A concatameric protein comprising two soluble domains, in which a N-terminus of a soluble domain of a biologically active protein is linked to C- terminus of an identical soluble domain or a different soluble domain of a biologically active protein.
A concatameric fusion dimeric protein comprising two monomeric proteins formed by linkage of a concatamer of two identical soluble extracellular domains of proteins involving immune response to a hinge region of an Fc fragment of an immunoglobulin molecule, wherein said monomeric proteins are linked by intermolecular disulfide bonds at the hinge region, and having improved stability and therapeutic effects.
A DNA construct encoding a monomeric protein formed by linkage of a concatamer of two identical soluble extracellular domains of a protein involving immune response to a hinge region of an Fc fragment of an immunoglobulin molecule.
A concatameric fusion dimeric protein comprising two monomeric proteins formed by linkage of a concatamer of two identical soluble extracellular domains of proteins involving immune response to the hinge region of Fc fragment of an immunoglobulin molecule, wherein said monomeric proteins are linked by formation of intermolecular disulfide bonds at the hinge region and glycosylated, and having improved stability and therapeutic effects.
A DNA construct encoding a monomeric protein formed by linkage of a concatamer of two identical soluble extracellular domains of proteins involving immune response to a hinge region of an Fc fragment of an immunoglobulin molecule and containing glycosylation motif peptides.
Dependencies are inferred from the claim text.