UL16 binding protein 4
AssigneeImmunex Corporation
InventorDavid J. Cosman
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Abstract
ULBP4, a novel member of the ULBP family has been isolated and characterized. ULBP4 is a useful activator of immune effector cells, particularly of NK cells.
Claims47
An isolated ULBP4 protein comprising a polypeptide consisting of an amino acid sequence at least 92% identical to amino acids 32 to 207 of SEQ ID NO:
- 2,
- wherein the polypeptide can bind to NKG2D.
An isolated ULBP4 polynucleotide comprising a nucleic acid consisting of a nucleotide sequence at least 95% identical to residues 94 to 621 of SEQ ID NO:
- 1, wherein the nucleic acid encodes a polypeptide that can bind to NKG2D.
An isolated ULBP4 polynucleotide encoding a ULBP4 protein comprising a polypeptide consisting of an amino acid sequence at least 92% identical to amino acids 32 to 207 of SEQ ID NO:
- 2, wherein the polypeptide can bind to NKG2D.
An isolated antibody that binds specifically to a protein consisting of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.