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US 2003/0195257 A1Published application
Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity
AssigneeSigma-Tau Industrie Farmaceutiche Riunite S.p.A.
InventorsNicola Fanto, Maria Ornella Tinti
Life of this patent
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Abstract
Formula (I) compounds are described, where the groups are defined in the description, as well as processes for their preparation and their use as medicaments, particularly as selective phosphodiesterase IV inhibitors. 1
Claims15
Formula (I) compounds
- 8
- where:
- R1 and R2, which may be the same or different, are halogen, hydroxy, straight or branched C1-C4 alkoxy, C5-C6 cycloalkoxy;
- X is —(CH2)n—, —CO—(CH2)n—, where n is 1 or 2, or X is —CH═;
- R3 is —OH, —NHOH, straight or branched C1-C4 alkoxy;
- Y is H, —(CH2)nCOR4, —COR4, —NHR5, where R4 is —OH, —NHOH, straight or branched C1-C4 alkoxy, R5 is H, C1-C4 alkanoyl optionally substituted by halogens;
- n is an integer between 1 and 4, extremes included;
- their enantiomers, diastereoisomers and mixtures of the same, and their pharmaceutically acceptable salts.
5 more elements
Compounds according to claim, in which R is —OH.
Dependencies are inferred from the claim text.