Novel approach to anti-microbial host defense with molecular shields with lipoxin compounds
OwnerCharles N. Serhan, Sean P. Colganinventors
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Abstract
Methods to cause tissue, such as mucosal cells, to express increased amounts of bactericidal permeability increasing protein (BPI) are described. The BPI inducing agents include, for example, lipoxin compounds.
Claims25
A method for the stimulation of bactericidal permeability increasing protein (BPI) in a subject's tissue, comprising the step of administering a therapeutically effective amount of lipoxin or a lipoxin analog, such that the subject's tissues express increased levels of BPI to treat infection.
A method for the stimulation of bactericidal permeability increasing protein (BPI) in a mucosal cell, comprising the step of administering a therapeutically effective amount of lipoxin or a lipoxin analog, such that the mucosal cell expresses increased levels of BPI to treat infection.
A method for inhibition or prevention of infection by bacteria in a subject, comprising the step of administering a therapeutically effective amount of a-lipoxin or lipoxin analog to the subject suitable to cause mucosal cells in the subject to express increased levels of BPI, such that infection by bacteria in the subject is prevented or inhibited.
A method for inhibition or prevention of invasion by bacteria in a subject, comprising the step of administering a therapeutically effective amount of a lipoxin or lipoxin analog to the subject suitable to cause mucosal cells in the subject to express increased levels of BPI, such that invasion by bacteria in the subject is prevented or inhibited.
Dependencies are inferred from the claim text.