Combination therapy comprising glucose reabsorption inhibitors and retinoid-x receptor modulators
OwnerJacqueline C. Bussolari, Xiaoli Chen +4inventors
InventorsJacqueline C. Bussolari, Xiaoli Chen, Bruce R. Conway, Keith T. Demarest, Hamish N.M. Ross, Rafael Severino
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Abstract
Combination therapy comprising RXR modulators and glucose reabsorption inhibitors useful for the treatment of diabetes and Syndrome X are disclosed.
Claims79
A method for treating diabetes or Syndrome X, or associated symptoms or complications thereof in a subject, comprising
- (a) administering to said subject a jointly effective amount of a glucose reabsorption inhibitor;
- and
- (b) administering to said subject a jointly effective amount of an RXR modulator,
- said co-administration being in any order and the combined jointly effective amounts providing the desired therapeutic effect.
A method for inhibiting the onset of diabetes or Syndrome X, or associated symptoms or complications thereof in a subject, said method comprising
- (a) administering to said subject a jointly effective amount of a glucose reabsorption inhibitor;
- and
- (b) administering to said subject a jointly effective amount of an RXR modulator,
- said co-administration being in any order and the combined jointly effective amounts providing the desired prophylactic effect.
A pharmaceutical composition comprising a glucose reabsorption inhibitor, a RXR modulator, and a pharmaceutically acceptable carrier.
A process for formulating a pharmaceutical composition, comprising formulating together a glucose reabsorption inhibitor, an RXR modulator, and a pharmaceutically acceptable carrier.
A process for making a pharmaceutical composition comprising mixing one or more glucose reabsorption inhibitors in combination with an RXR modulator for the preparation of a medicament for treating a condition selected from IDDM, NIDDM, IGT, IFG, obesity, nephropathy, neuropathy, retinopathy, atherosclerosis, polycystic ovary syndrome, hypertension, ischemia, stroke, heart disease, irritable bowel disorder, inflammation, and cataracts.
A method for inhibiting the progression of a prediabetic condition in a subject to a diabetic condition, comprising
- (a) administering to said subject a jointly effective amount of a glucose reabsorption inhibitor;
- and
- (b) administering to said subject a jointly effective amount of an RXR modulator,
- said co-administration being in any order and the combined jointly effective amounts providing the desired inhibiting effect.
Dependencies are inferred from the claim text.