Hybrid 2-aminotetralin and aryl-substituted piperazine compounds and their use in altering cns activity

A compound exhibiting CNS activity in mammalian species, having the structure

• 10
• wherein A is an optionally heterocyclic aromatic ring system:
• 11
• is an optionally heterocyclic 5 or 6 membered aromatic ring structure;
• R2 is an organyl group substituent or two R2 together may form a fused ring system,
• o is an integer from 0 to 4, the upper limit of o bounded by the number of available substituent sites;
• m is 0 or 1;
• n is an integer from 0 to 4 when m=0, and when m=1, n is an integer from 0 to 2;
• R is H, C1-4 alkyl, C1-4 alkoxy, cyano, or when m=1, R is a methylene group bonded to (CH);
• R1 is an organyl group;
• p is 1 to 4;
• wherein one (CH2)n group may be replaced by O or S;
• or a pharmaceutically acceptable derivative thereof.