Compounds effective as beta-2 adrenoreceptor agonists as well pde4-inhibitors

Compounds of formula I

• 41
• in which
• Ar1 represents a phenyl radical of formula (Ia) substituted by R1 and R2 or a dihydrobenzofuranyl radical of formula (Ib) substituted by R3, R4 and R5
• 42
• wherein
• R1 is hydroxyl, halogen, 1-4C-alkoxy or 1-4C-alkoxy which is completely or predominantly substituted by fluorine,
• R2 is hydroxyl, halogen, 1-8C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine,
• R3 is 1-4C-alkoxy, 3-5C-cycloalkoxy, 3-5C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine,
• R4 is 1-4C-alkyl and
• R5 is hydrogen or 1-4C-alkyl,
• or wherein
• R4 and R5 together and with inclusion of the two carbon atoms, to which they are bonded, form a spiro-linked 5-, 6- or 7-membered hydrocarbon ring, optionally interrupted by an oxygen or sulphur atom,
• R6 and R7 represent independently from one another hydrogen or 14C-alkyl, or R6 and R7 together and with inclusion of the two carbon atoms, to which they are bonded, form a group selected from
• 43
• A represents —CmH2m—Y—X—CnH2n— or —Y—X—CmH2m—Z—CnH2n—, wherein
• X represents a bond, —O— (oxygen), —S— (sulfur), —NH—, —C(O)—, —S(O)2—, —C(O)—NH—, —NH—C(O)—, —C(S)—NH—, —NH—C(S)—, —NH—C(O)—NH— or —NH—C(S)—NH—,
• Y represents a bond, phenylene, 4-8C-cycloalkylene or azacycloalkylene,
• Z represents —O—, —S—, —S(O)2—, —NH—C(O)—, —C(O)—NH—, —NH—C(S)— or —C(S)—NH—,
• m is an integer from 0 to 4,
• n is an integer from 1 to 4,
• R8 is hydrogen or 1-4C-alkyl,
• Ar2 represents a 8-hydroxy-1H-quinolin-2-on-5-yl radical or a phenyl radical substituted by R9, R10 and R11,
• wherein
• R9 is hydrogen, halogen, hydroxyl, amino, ureido [—NH—C(O)—NH2], formylamino [—NH—C(O)H], 1-4C-alkylcarbonylamino, di-1-4C-alkylaminocarbonyloxy, tolylcarbonyloxy [—OC(O)—C6H4—CH3], hydroxymethyl, 1-4C-alkylcarbonyloxy, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkylsulfonylamino, 1-4C-alkylsulfonylmethyl or 1-4C-alkoxy-1-4C-alkyl,
• R10 is hydrogen, halogen, hydroxyl, cyano, trifluoromethyl, tolylcarbonyloxy [—O—C(O)—C6H4—CH3], hydroxymethyl or 1-4C-alkylcarbonyloxy,
• R11 is hydrogen or halogen,
• and the salts of these compounds.