Urea substituted imidazopyridines

A compound of the formula (I):

• 72
• wherein
• X is alkylene or alkenylene;
• Y is —CO— or —CS—;
• Z is —NR6—;
• —NR6—CO—;
• —NR6—SO2—;
• or —NR7—;
• R1 is aryl, heteroaryl, heterocyclyl, alkyl or alkenyl, each of which may be unsubstituted or substituted by one or more substituents independently selected from the group consisting of:
• -alkyl;
• -alkenyl;
• -aryl;
• -heteroaryl;
• -heterocyclyl;
• -substituted cycloalkyl;
• -substituted aryl;
• -substituted heteroaryl;
• substituted heterocyclyl;
• —O-alkyl;
• —O-(alkyl)0-1-aryl;
• —O-(alkyl)0-1-substituted aryl;
• —O-(alkyl)0-1-heteroaryl;
• —O-(alkyl)0-1-substituted heteroaryl;
• —O-(alkyl)0-1-heterocyclyl;
• —O-(alkyl)0-1-substituted heterocyclyl;
• —COOH;
• —CO—O-alkyl;
• -CO-alkyl;
• —S(O)0-2-alkyl;
• —S(O)0-2-(alkyl)0-1-aryl;
• —S(O)0-2-(alkyl)0-1-substituted aryl;
• —S(O)0-2-(alkyl)0-1-heteroaryl;
• —S(O)0-2-(alkyl)0-1-substituted heteroaryl;
• —S(O)0-2-(alkyl)0-1-heterocyclyl;
• —S(O)0-2-(alkyl)0-1-substituted heterocyclyl;
• -(alkyl)0-1-N(R6)2;
• -(alkyl)0-1-NR6—CO—O-alkyl;
• -(alkyl)0-1-NR6—CO-alkyl;
• -(alkyl)0-1-NR6—CO-aryl;
• -(alkyl)0-1-NR6—CO-substituted aryl;
• -(alkyl)0-1-NR6—CO-heteroaryl;
• -(alkyl)0-1-NR6—CO-substituted heteroaryl;
• —P(O)(Oalkyl)2;
• —N3;
• -halogen;
• -haloalkyl;
• -haloalkoxy;
• —CO-haloalkyl;
• —CO-haloalkoxy;
• —NO2;
• —CN;
• —OH;
• —SH;
• and in the case of alkyl, alkenyl, and heterocyclyl, oxo;
• R2 is selected from the group consisting of:
• -hydrogen;
• -alkyl;
• -alkenyl;
• -aryl;
• -substituted aryl;
• -heteroaryl;
• -substituted heteroaryl;
• -alkyl-O-alkyl;
• -alkyl-S-alkyl;
• -alkyl-O-aryl;
• -alkyl-S-aryl:
• -alkyl-O— alkenyl;
• -alkyl-S— alkenyl;
• and
• -alkyl or alkenyl substituted by one or more substituents selected from the group consisting of:
• —OH;
• -halogen;
• —N(R6)2;
• —CO—N(R6)2;
• —CS—N(R6)2;
• —SO2—N(R6)2;
• —NR6—CO—C1-10 alkyl;
• —NR6—CS—C1-10 alkyl;
• —NR6—SO2—C1-10 alkyl;
• —CO—C1-10 alkyl;
• —CO—O—C1-10 alkyl;
• —N3;
• -aryl;
• -substituted aryl;
• -heteroaryl;
• -substituted heteroaryl;
• -heterocyclyl;
• -substituted heterocyclyl;
• —CO-aryl;
• —CO-(substituted aryl);
• —CO-heteroaryl;
• and
• —CO-(substituted heteroaryl);
• R3 and R4 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, halogen, alkoxy, amino, alkylamino, dialkylamino and alkylthio;
• R5 is H or C1-10 alkyl, or R5 can join with X to form a ring that contains one or two hetero atoms;
• each R6 is independently H or C1-10 alkyl;
• R7 is H or C1-10 alkyl which may be interrupted by a heteroatom or when R1 is alkyl, R7 and R1 can join to form a ring;
• or a pharmaceutically acceptable salt thereof.