Heterocyclic derivatives

A compound of formula (I)

• A—B—X1—T1(R2)—L1—T2(R3)—X2—Q (I)
• wherein:
• A is 5- or 6-membered monocyclic aromatic ring containing 1, 2 or 3 ring heteroatoms selected form nitrogen, oxygen and sulphur atoms optionally substituted by one, two or three atoms or groups selected from halo, oxo, carboxy, trifluoromethyl cyano, amino, hydroxy, nitro, C1-4alkyl (for example methyl or ethyl), C1-4alkoxy (for example methoxy or ethoxy), C1-4alkoxycarbonyl, C1-4alkylamino (for example methylamino or ethylamino) or di-C1-4alkylamino (for example dimethylamino or diethylamino);
• B is a phenylene ring optionally substituted by one or two substituents selected from halo, trifluoromethyl, trifluoromethoxy, cyano, nitro, C1-4alkyl, C2-4alkenyl and C2-4alkynyl, from the substituent —(CH2)nY1 wherein n is 0-4 and Y1 is selected from hydroxy, amino, carboxy, C1-4alkoxy, C2-4alkenyloxy, C1-4alkynyloxy, C1-4alkylamino, di-C1-4alkylamino, pyrrolidin-1-yl, piperidino, morpholino, thiomorpholino, 1-oxothiomorpholino, 1,1-dioxothiomorpholino, piperazin-1-yl, 4-C1-4alkylpiperazin-1-yl, C1-4alkylthio, C1-4-alkylsulphinyl, C1-4alkylsulphonyl, C2-4alkanoylamino, benzamido, C1-4alkylsulphonamido and phenylsulphonamido, from the substituent —(CH2)nY1 wherein n is 0-4 and Y2 is selected from carboxy, carbamoyl, C1-4alkoxycarbonyl, N—C1-4alkylcarbamoyl, N,N-di-C1-4-alkylcarbamoyl, pyrrolidin-1-ylcarbonyl, piperidinocarbonyl, morpholinocarbonyl, thiomorpholinocarbonyl,
• 1-oxothiomorpholinocarbonyl, 1,1 dioxothiomorpholinocarbonyl, piperazin-1-ylcabonyl, 4-C1-4alkylpiperazin-1-ylcarbonyl C1-4alkylsulphonamidocarbonyl, phenylsulphonamidocarbonyl and benzylsulphonamidocarbonyl, from a substituent of the formula —X3-L2-Y3 wherein X3 is a group of the formula CON(R5), CON(L2-Y2), C(R5)2O, O, N(R5) or N(L2-Y2), L2 is C1-4alkylene, Y2 has any of the meanings defined immediately hereinbefore and each R5 is independently hydrogen or C1-4alkyl, and from a substituent of the formula —X3-L3-Y1 wherein X3 is a group of the formula CON(R5), CON(L3-Y1), C(R5)2O, O, N(R5) or N(L3-Y1), L3 is C2-4alkylene, Y1 has any of the meanings defined immediately hereinbefore and each R5 is independently hydrogen or C1-4alkyl, and wherein any heterocyclic group in a substituent of B optionally bears 1 or 2 substituents selected from carboxy, carbamoyl, C1-4alkyl, C1-4alkoxycarbonyl, N—C1-4alkylcarbamoyl and N,N-di-C1-4alkylcarbamoyl, and wherein any phenyl group in a substituent of B optionally bears 1 or 2 substituents selected from halo, trifluoromethyl, cyano, C1-4alkyl, C2-4alkenyl, C2-4alkyl,
• C1-4alkoxy, C2-4alkenyloxy and C2-4alkynyloxy;
• T1 is CH or N;
• T2 is CH or N;
• with the proviso that at least one of T1 and T2 is N and wherein the heterocyclic ring formed by T1, T2, L1, R2 and R3 is optionally substituted by one or two substituents selected from hydroxy, oxo, carboxy and C1-4alkoxycarbonyl;
• or one of the following:
• —(CH2)n—R, —(CH)n—NRR1, —CO—R, —CO—NRR1, —(CH2)n—CO—R and —(CH2)n—CO—NRR1;
• wherein n is 0, 1 or 2, preferably n is 1 or 2;
• R and R1 are independently selected from hydrogen, C1-4alkyl, C2-4alkenyl, C1-4alkynyl, hydroxyC1-4alkyl, carboxyC1-4alkyl and C1-4alkoxycarbonylC1-4alkyl or where possible R and R1 may together form a 5- or 6-membered optionally substituted saturated or partially unsaturated (preferably saturated) heterocyclic ring which may include in addition to the nitrogen to which R and R1 are attached 1 or 2 additional heteroatoms selected from nitrogen, oxygen and sulphur
• X1 is SO, SO2, C(R4)2 or CO when T1 is CH or N;
• or in addition X1 is O or S when T1 is CH;
• and wherein each R4 is independently hydrogen or C1-4alkyl;
• L1 is C1-4alkylene or C1-3alkylenecarbonyl;
• R2 is hydrogen or C1-4alkyl;
• R3 is hydrogen or C1-4alkyl;
• or R2 and R3 are joined to form a C1-4alkylene or —CH2CO— group;
• wherein the ring formed by T1, R2, R3, T2 and L1 is optionally substituted;
• with the proviso that when T1 and T2 are both N, L1 is not methylene and R2 and R3 together are not methylene;
• X2 is S(O)y wherein y is one or two, C(R5)2 or CO;
• and each R5 is hydrogen or C1-4alkyl;
• Q is phenyl, naphthyl, phenylC1-4alkyl, phenylC1-4alkenyl, phenylC2-4alkynyl or a heterocyclic moiety containing up to 4 heteroatoms selected from nitrogen, oxygen and sulphur and Q is optionally substituted by one, two or three substituents selected from halo, trifluromethyl, trifluoromethoxy, cyano, hydroxy, amino, nitro, trifluoromethylsulphonyl, carboxy, carbamoyl, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy, C2-4alkenyloxy, C2-4alkynyloxy, C1-4alkylthio, C1-4alkylsulphinyl, C1-4alkylsulphonyl, C1-4alkylamino, di-C1-4alkylamino, C1-4-alkoxycarbonyl, N—C1-4alkylcarbamoyl, N,N-di-C1-4alkylcarbamoyl, C2-4alkanoyl, C2-4-alkanoylamino, hydroxyC1-4alkyl, C1-4alkoxyC1-4alkyl, carboxyC1-4alkyl, C1-4-alkoxycarbonylC104alkyl, carbamoylC1-4alkyl, N—C1-4alkylcarbamoylC1-4alkyl, N,N-di-C1-4-alkylcarbamoylC1-4alkyl, phenyl, heteroaryl, phenoxy, phenylthio, phenylsulphinyl, phenylsulphonyl, benzyl, benzoyl, heteroaryloxy, heteroarylthio, heteroarylsulphinyl and heteroarylsulphonyl, and wherein said heteroaryl substituent or the heteroaryl group in a heteroaryl-containing substituent is a 5- or 6-membered monocyclic heteroaryl ring containing up to 3 heteroatoms selected from nitrogen, oxygen and sulphur, and wherein said phenyl, heteroaryl, phenoxy, phenylthio, phenylsulphinyl, phenylsulphonyl, heteroaryloxy, heteroarylthio, heteroarylsulphinyl, heteroarylsulphonyl, benzyl or benzoyl substituent optionally bears 1, 2 or 3 substituents selected from halo, trifluoromethyl, cyano, hydroxy, amino, nitro, carboxy, carbamoyl, C1-4alkyl, C1-4alkoxy, C1-4alkylamino, di-C1-4alkylamino, C1-4alkoxycarbonyl, N—C1-4alkylcarbamoyl, N,N-di-C1-4alkylcarbamoyl and C2-4alkanoylamino;
• and pharmaceutically acceptable salts thereof.