Nicotinamides having antiangiogenic activity

A compound of formula (I)

• 4
• or a therapeutically acceptable salt thereof, wherein
• A1, A2, A3, and A4 are each independently selected from the group consisting of N and CR3;
• with the proviso that at least two of A1, A2, A3, and A4 are CR3;
• R1 and R2, together with the nitrogen atom to which they are attached, form a five- to eight-membered ring containing an additional zero to two heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur;
• wherein the ring can be optionally substituted with one, two, or three substituents independently selected from the group consisting of alkoxycarbonyl, alkyl, aminocarbonyl, aryl, arylalkyl, formyl, haloalkyl, heterocycle, (heterocycle)alkyl, hydroxy, hydroxyalkyl, and spiroheterocycle;
• each R3 is independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylsulfanyl, amino, aminocarbonyl, aryl, arylalkyl, cyano, cyanoalkyl, cycloalkyl, (cycloalkyl)alkyl, halo, haloalkyl, heterocycle, hydroxy, hydroxyalkyl, and nitro;
• and
• X is selected from the group consisting of O, S, and CH2.